Identifying novel circulating biomarkers predictive of response and informative about the
mechanisms of resistance, is the new challenge for breast cancer (BC) management. The …

Adaptive and innate immune cells play a crucial role as regulators of cancer development.
Inflammatory cells in blood flow seem to be involved in pro-tumor activities and contribute to …

Immune-checkpoint inhibitors (ICIs) have widened the therapeutic scenario of different
cancer types. Phase I/II trials have been designed to evaluate the role of ICIs both as single …

Objective: Squamous cell carcinoma (SCC) represents the most common histotype of all head
and neck malignancies and includes oropharyngeal squamous cell carcinoma (OSCC), a …

Background Soft tissue sarcomas (STS) are a rare group of solid neoplasm including
among others liposarcoma, leiomyosarcoma (L-sarcoma) and undifferentiated pleomorphic …

Background: Neuroendocrine neoplasias (NENs) are a rare group of tumors with different
prognosis and response to therapy. Their heterogeneity is dependent on the site of origin, …

Gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) are a rare and heterogeneous
subgroup of tumors with a challenging management because of their extremely variable …

Background Induction chemotherapy (IC) added to concurrent chemoradiotherapy (CCRT)
appears to be superior to CCRT alone for locally-advanced nasopharyngeal carcinoma (NPC…

Adult rhabdomyosarcoma (RMS) represents an uncommon entity with an incidence of less
than 3% of all soft tissue sarcomas (STS). Consequently, the natural history and the clinical …

Introduction Cyclin-dependent kinase 4/6 (CDK4/6) inhibitors have an extremely important
impact on the treatment of hormone-sensitive breast cancer (BC) and have radically changed …