Effect of polymorphisms in folate-related genes on in vitro methotrexate sensitivity in pediatric acute lymphoblastic leukemia
…, G Jansen, CH van Zantwijk, GJL Kaspers… - Blood, 2005 - ashpublications.org
We studied whether common polymorphisms in genes involved in folate metabolism affect
methotrexate (MTX) sensitivity. Ex vivo MTX sensitivity of lymphoblasts obtained from …
methotrexate (MTX) sensitivity. Ex vivo MTX sensitivity of lymphoblasts obtained from …
Molecular drug imaging: 89Zr-bevacizumab PET in children with diffuse intrinsic pontine glioma
…, GA van Dongen, GJL Kaspers - Journal of Nuclear …, 2017 - Soc Nuclear Med
Predictive tools for guiding therapy in children with brain tumors are urgently needed. In this
first molecular drug imaging study in children, we investigated whether bevacizumab can …
first molecular drug imaging study in children, we investigated whether bevacizumab can …
Cellular drug resistance profiles in childhood acute myeloid leukemia: differences between FAB types and comparison with acute lymphoblastic leukemia
CM Zwaan, GJL Kaspers, R Pieters… - Blood, The Journal …, 2000 - ashpublications.org
Determining in vitro drug resistance may reveal clinically relevant information in childhood
leukemia. Using the methyl-thiazol-tetrazolium assay, the resistance of untreated leukemic …
leukemia. Using the methyl-thiazol-tetrazolium assay, the resistance of untreated leukemic …
[HTML][HTML] Effect of dexamethasone on quality of life in children with acute lymphoblastic leukaemia: a prospective observational study
…, MA Grootenhuis, AB Versluys, GJL Kaspers… - Health and Quality of …, 2008 - Springer
Background Glucocorticoids are important in the treatment of childhood acute lymphoblastic
leukaemia (ALL). However, cyclic administration of high dose glucocorticoids may cause …
leukaemia (ALL). However, cyclic administration of high dose glucocorticoids may cause …
Glucocorticoid resistance in childhood leukaemia: mechanisms and modulation.
EG Haarman, GJL Kaspers… - British journal of …, 2003 - search.ebscohost.com
Summarizes efforts to elucidate the molecular mechanisms of glucocorticoids (GC) which
are a central component in contemporary pediatric acute lymphoblastic leukemia treatment …
are a central component in contemporary pediatric acute lymphoblastic leukemia treatment …
Differential methotrexate resistance in childhood T-versus common/preB-acute lymphoblastic leukemia can be measured by an in situ thymidylate synthase inhibition …
MG Rots, R Pieters, GJL Kaspers… - Blood, The Journal …, 1999 - ashpublications.org
Methotrexate (MTX) is not cytotoxic to patient-derived acute lymphoblastic leukemia (ALL)
cells in total-cell-kill assays, such as the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium …
cells in total-cell-kill assays, such as the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium …
Reduced folate carrier mutations are not the mechanism underlying methotrexate resistance in childhood acute lymphoblastic leukemia
…, MWB Arush, R Elhasid, D Sahar, GJL Kaspers… - Cancer, 2004 - Wiley Online Library
BACKGROUND Although the majority of children with acute lymphoblastic leukemia (ALL)
are cured with combination chemotherapy containing methotrexate (MTX), drug resistance …
are cured with combination chemotherapy containing methotrexate (MTX), drug resistance …
Kaposiform (spindle cell) hemangioendotelioma in a child with an unusual presentation
…, JI Verbeke, MM Witbreuk, GJL Kaspers - Journal of Pediatric …, 2010 - journals.lww.com
We describe a male child with multifocal kaposiform hemangioendothelioma in the right and
left cervical region with development of Kasabach-Merritt syndrome. Treatment with …
left cervical region with development of Kasabach-Merritt syndrome. Treatment with …
Modulation of metabolism and cytotoxicity of cytosine arabinoside with N-(phosphon)-acetyl-L-aspartate in human leukemic blast cells and cell lines
P Noordhuis, KM Kazemier, GJL Kaspers, GJ Peters - Leukemia research, 1996 - Elsevier
Cytosine arabinoside (Ara-C) activation to cytosine arabinoside triphosphate (Ara-CTP) and
subsequent incorporation into DNA is regulated by the pyrimidine nucleotides UTP, CTP …
subsequent incorporation into DNA is regulated by the pyrimidine nucleotides UTP, CTP …
Cytosine arabinoside: Metabolism, mechanisms of Resistance, and clinical pharmacology
I Hubeek, GJL Kaspers, GJ Ossenkoppele… - … Analogs in Cancer …, 2006 - Springer
The deoxynucleoside analog cytarabine (ara-C) remains one of the most effective drugs
used in the treatment of acute leukemia as well as other hematopoietic malignancies. The …
used in the treatment of acute leukemia as well as other hematopoietic malignancies. The …