Background Among patients with non–small-cell lung cancer (NSCLC), data on intratumor
heterogeneity and cancer genome evolution have been limited to small retrospective cohorts. …

The early detection of relapse following primary surgery for non-small-cell lung cancer and
the characterization of emerging subclones, which seed metastatic sites, might offer new …

Immune evasion is a hallmark of cancer. Losing the ability to present neoantigens through
human leukocyte antigen (HLA) loss may facilitate immune evasion. However, the …

With the use of a mouse model expressing human Fc-gamma receptors (FcγRs), we
demonstrated that antibodies with isotypes equivalent to ipilimumab and tremelimumab mediate …

CD25 is expressed at high levels on regulatory T (Treg) cells and was initially proposed as
a target for cancer immunotherapy. However, anti-CD25 antibodies have displayed limited …

The importance of intratumour genetic and functional heterogeneity is increasingly recognised
as a driver of cancer progression and survival outcome. Understanding how tumour …

Background and Aims: Hepatotoxicity, especially liver fibrosis, is the major concern with long‐term,
‘low‐dose’ oral methotrexate (MTX) therapy for psoriasis. The histological features …

Background Radical surgery via total mesorectal excision might not be the optimal first-line
treatment for early-stage rectal cancer. An organ-preserving strategy with selective total …

Background: Tumor levels of steroid hormone receptors, a factor used to select adjuvant
treatment for early-stage breast cancer, are currently determined with immunohistochemical …

BACKGROUND: The detection of lymph node involvement is fundamental to the staging of
rectal cancer, and aids in prognostication and identification of patients who will benefit from …