Interleukin-12 (IL-12) has emerged as one of the most potent agents for anti-tumor immunotherapy.
However, potentially lethal toxicity associated with systemic administration of IL-12 …

Background and aims Metastasis accounts for the poor outcome of patients with pancreatic
cancer. We recently discovered PRSS3 to be over-expressed in metastatic human pancreatic …

Purpose: Vaccinia virus has strong potential as a novel therapeutic agent for treatment of
pancreatic cancer. We investigated whether arming vaccinia virus with interleukin-10 (IL10) …

Purpose: The efficacy of oncolytic viruses depends on multiple actions including direct tumor
lysis, modulation of tumor perfusion, and stimulation of tumor-directed immune responses. …

Background Local recurrence and remote metastasis are major challenges to overcome in
order to improve the survival of patients with cancer after surgery. Oncolytic viruses are a …

Survival after pancreatic cancer remains poor despite incremental advances in surgical and
adjuvant therapy, and new strategies for treatment are needed. Oncolytic virotherapy is an …

Purpose: Pancreatic cancer remains one of the most lethal cancers, and late detection renders
most tumors refractory to conventional therapies. Development of cancer prophylaxis may …

The Kunlun Pass Basin, located in the middle of the eastern Kunlun Mountains, received
relatively continuous late Cenozoic sediments from the surrounding mountains, archiving great …

The changes in cancer cell surface molecules and intracellular signaling pathways during
tumorigenesis make delivery of adenovirus-based cancer therapies inefficient. Here we have …

BACKGROUND Multiple sites of metastasis and desmoplastic reactions in the stroma are
key features of human pancreatic cancer (PC). There are currently no simple and reliable …