A novel coronavirus known as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
has spread across the world, prompting the World Health Organization to declare the …

Angiotensin-converting enzyme (ACE) can cleave angiotensin I, bradykinin, neurotensin and
many other peptide substrates in vitro. In part, this is due to the structure of ACE, a protein …

During carcinogenesis, tumors induce dysfunctional development of hematopoietic cells.
Myeloid lineage cells, in the form of myeloid derived suppressor cells (MDSCs) and …

The surface presentation of peptides by major histocompatibility complex (MHC) class I
molecules is critical to CD8 + T cell–mediated adaptive immune responses. Aminopeptidases …

PURPOSE: The role of consolidative radiation therapy (RT) after complete response (CR) to
rituximab combined with cyclophosphamide, doxorubicin, vincristine, and prednisone (R-…

Granulocytes are key players in cancer metastasis. While tumor-induced de novo expansion
of immunosuppressive myeloid-derived suppressor cells (MDSCs) is well-described, the …

Metastatic melanoma is difficult to treat, and often portends a grim prognosis. For patients
with cerebral metastases, the prognosis is even more dire. Systemic immunotherapy and …

Background: Chronic renal inflammation has been widely recognized as a major promoter
of several forms of high blood pressure including salt-sensitive hypertension. In diabetes, IL (…

Inhibition of angiotensin-converting enzyme (ACE) induces anemia in humans and mice,
but it is unclear whether ACE is involved in other aspects of hematopoiesis. Here, we …

Background The purpose of this study was to describe the incidence and location of ipsilateral
breast tumor recurrence (IBTR) among breast cancer patients treated with oncoplastic …