Compelling evidence exists that non-haematopoietic stem cells, including mesenchymal (MSCs)
and neural/progenitor stem cells (NPCs), exert a substantial beneficial and therapeutic …

Mounting evidences support the idea that endogenous ‘biometals', such as copper, iron,
zinc and exogenous ones such as aluminum, can be involved as factors or cofactors in the …

The idea that stem cell therapies work only via cell replacement is challenged by the observation
of consistent intercellular molecule exchange between the graft and the host. Here we …

Amyloid-β 1–42 (Aβ) is believed to play a crucial role in the ethiopathogenesis of Alzheimer's
Disease (AD). In particular, its interactions with biologically relevant metal ions may lead to …

Pancreatic ductal adenocarcinoma (PDAC) is a lethal disease with high resistance to
therapies 1 . Inflammatory and immunomodulatory signals co-exist in the pancreatic tumour …

A significant co-morbidity of Alzheimer's disease and cerebrovascular impairment suggests
that cerebrovascular dysregulation is an important feature of dementia. Amyloid β protein (Aβ…

Mounting evidence suggests a central role for transition biometals in the etiopathogenesis
of neurodegenerative diseases (ND). Indeed, while studying the molecular basis for this …

Recent findings suggest that β-amyloid (Aβ) is more neurotoxic when present in its oligomeric
configuration rather than as monomers or fibrils. Previous work from our laboratories has …

The etiopathogenesis of Alzheimer's disease is far from being clearly understood. However,
the involvement of metal ions as a potential key factor towards conformational modifications …

Innovative pro-regenerative treatment strategies for progressive multiple sclerosis (PMS),
combining neuroprotection and immunomodulation, represent an unmet need. Neural …