[HTML][HTML] The potential for liquid biopsies in the precision medical treatment of breast cancer

VA Forte, DK Barrak, M Elhodaky, L Tung… - Cancer biology & …, 2016 - ncbi.nlm.nih.gov
Currently the clinical management of breast cancer relies on relatively few prognostic/predictive
clinical markers (estrogen receptor, progesterone receptor, HER2), based on primary …

Field Defect in Esophageal Cancer: A Stochastic Evolution in Cancer Biology

DK Barrak, R Deldar, SA Halbert… - The Annals of …, 2022 - annalsthoracicsurgery.org
The revolutionary concept of field defect, also known as field effect or field cancerization, was
introduced by Slaughter and colleagues 1 in 1953. After observing numerous similarities in …

Total neoadjuvant treatment for pancreatic ductal adenocarcinoma is associated with limited lymph node yield but improved ratio

D Barrak, AM Villano, MA Moslim, SE Hopkins… - Journal of Surgical …, 2022 - Elsevier
Introduction The lymph node yield (LNY) and lymph node ratio (LNR) of nodal metastases
following pancreatoduodenectomy (PD) have been reported as prognostic parameters in …

Total neoadjuvant therapy for pancreatic adenocarcinoma increases probability for a complete pathologic response

D Barrak, AM Villano, N Villafane-Ferriol… - European Journal of …, 2022 - Elsevier
Background Multiple neoadjuvant therapy protocols have been proposed in the treatment of
pancreatic adenocarcinoma, including chemotherapy (CT), chemoradiation (CRT), and total …

Type of neoadjuvant treatment strategy is associated with differential pathologic responses in pancreatic ductal adenocarcinoma

…, AM Villano, SP Reddy, K Devarajan, D Barrak… - The American Journal of …, 2023 - Elsevier
Background Tumor fibrosis after neoadjuvant treatment (NAT) for pancreatic ductal adenocarcinoma
(PDAC) correlates with treatment response. Herein we assessed how different NAT …

Robot-assisted combined pancreatectomy/hepatectomy for metastatic pancreatic acinar cell carcinoma: case report and review of the literature

AM Villano, D Barrak, A Jain, E Meslar… - Clinical Journal of …, 2020 - Springer
Acinar cell carcinoma (ACC) of the pancreas is a rare neoplasm with less aggressive behavior
than ductal carcinoma. As a result, surgical resection for metastatic ACC is a therapeutic …

Regionalization of retroperitoneal sarcoma surgery to high-volume hospitals: missed opportunities for outcome improvement

AM Villano, A Zeymo, J McDermott, D Barrak… - Journal of Oncology …, 2019 - ascopubs.org
PURPOSE: Surgery continues to be the dominant therapy for the management of retroperitoneal
soft-tissue sarcoma (RPS). Many groups advocate performing these resections at high-…

Survival from a 75% TBSA thermal injury complicated by bowel ischemia presenting with pneumatosis intestinalis

R Caso, D Barrak, TE Travis… - Journal of Surgical …, 2018 - academic.oup.com
Thermal injury is associated with an increased risk of abdominal complications such as
ischemia, infarction and pneumatosis intestinalis (PI). PI is characterized by gas in the intestinal …

Total neoadjuvant therapy is associated with improved overall survival and pathologic response in pancreatic adenocarcinoma

…, E O'Halloran, N Goel, K Ruth, D Barrak… - Journal of surgical …, 2022 - Wiley Online Library
Background Few studies have evaluated outcomes of total neoadjuvant therapy (TNT)
compared with single modality neoadjuvant therapy (SMNT) or surgery first (SF) for pancreatic …

[HTML][HTML] EpCAM based capture detects and recovers circulating tumor cells from all subtypes of breast cancer except claudin-low

…, W Zhu, E Park, C Lomas, V Punj, M Yu, D Barrak… - Oncotarget, 2015 - ncbi.nlm.nih.gov
Purpose The potential utility of circulating tumor cells (CTCs) as liquid biopsies is of great
interest. We hypothesized that CTC capture using EpCAM based gating is feasible for most …