[HTML][HTML] Complications of deep brain stimulation: a collective review

DTM Chan, XL Zhu, JHM Yeung, VCT Mok… - Asian journal of …, 2009 - Elsevier
BACKGROUND: Since the first deep brain stimulation (DBS) performed for movement
disorder more than a decade ago, DBS has become a standard operation for advanced …

Patient-derived tumor organoid predicts drugs response in glioblastoma: A step forward in personalized cancer therapy?

HHF Loong, AM Wong, DTM Chan… - Journal of Clinical …, 2020 - Elsevier
Despite significant medical advances, glioblastoma multiforme (GBM) remains a formidable
therapeutic challenge. Advent of targeted capture sequencing and patients-derived …

[HTML][HTML] Loss of brain-enriched miR-124 microRNA enhances stem-like traits and invasiveness of glioma cells

…, S Jiang, J Sze, GKK Leung, G Lu, DTM Chan… - Journal of Biological …, 2012 - ASBMB
miR-124 is a brain-enriched microRNA that plays a crucial role in neural development and
has been shown to be down-regulated in glioma and medulloblastoma, suggesting its …

scONE-seq: A single-cell multi-omics method enables simultaneous dissection of phenotype and genotype heterogeneity from frozen tumors

…, DSC Loi, AKY Chan, WS Poon, HK Ng, DTM Chan… - Science …, 2023 - science.org
Single-cell multi-omics can provide a unique perspective on tumor cellular heterogeneity.
Most previous single-cell whole-genome RNA sequencing (scWGS-RNA-seq) methods …

[HTML][HTML] How useful is glucose detection in diagnosing cerebrospinal fluid leak? The rational use of CT and Beta-2 transferrin assay in detection of cerebrospinal fluid …

DTM Chan, WS Poon, CP Ip, PWY Chiu… - Asian journal of surgery, 2004 - Elsevier
BACKGROUND: This report describes the sensitivity and specificity of glucose detection
using Glucostix test strips and computed tomography (CT) of the skull base for confirming …

Impact of metformin on immunological markers: Implication in its anti-tumor mechanism

…, PYM Woo, SCP Ng, GKC Wong, DTM Chan… - Pharmacology & …, 2020 - Elsevier
Metformin, an anti-hyperglycemic drug, has been known to have antitumor properties for
around 15 years. Although there are a number of reports attributing the antitumor function of …

[HTML][HTML] A multifaceted review of temozolomide resistance mechanisms in glioblastoma beyond O-6-methylguanine-DNA methyltransferase

…, Y Li, AHY Chan, SCP Ng, HHF Loong, DTM Chan… - Glioma, 2019 - journals.lww.com
Temozolomide (TMZ), an oral alkylating agent, is a cornerstone of standard-of-care multimodality
therapy for glioblastoma. In spite of significant efforts to treat this disease, the tumor …

[HTML][HTML] Epidemiological characteristics and genetic alterations in adult diffuse glioma in East Asian populations

Z Mo, J Xin, R Chai, PYM Woo, DTM Chan… - Cancer biology & …, 2022 - ncbi.nlm.nih.gov
Understanding the racial specificities of diseases—such as adult diffuse glioma, the most
common primary malignant tumor of the central nervous system—is a critical step toward …

Surgical video captioning with mutual-modal concept alignment

Z Chen, Q Guo, LKT Yeung, DTM Chan, Z Lei… - … Conference on Medical …, 2023 - Springer
Automatic surgical video captioning is critical to understanding surgical procedures, and
can provide the intra-operative guidance and the post-operative report generation. As the …

Cost-effectiveness of subthalmic nucleus deep brain stimulation for the treatment of advanced Parkinson disease in Hong Kong: a prospective study

XL Zhu, DTM Chan, CKY Lau, WS Poon, VCT Mok… - World neurosurgery, 2014 - Elsevier
… Author links open overlay panel XL Zhu 1 , Danny TM Chan 1 , Claire KY Lau 1 , Wai S.
Poon 1 , Vincent CT Mok 2 , Anne YY Chan 2 , Lawrence KS Wong 2 , Jonas HM Yeung 3 , …