Objectives: To investigate the expression of Igγ-1 chain C region (IGHG1) in human
pancreatic carcinomas and determine the biological function of IGHG1 expression in immune …

Background Hepatocellular carcinoma (HCC) is one of the leading causes of cancer deaths
worldwide. It is important to understand molecular mechanisms of HCC progression and to …

Background Recently, Accumulating evidence indicates that long noncoding RNAs (lncRNAs)
have been shown to have critical regulatory roles in human tumor biology and …

Background & Aims Epithelial‐mesenchymal transition ( EMT ) process and extracellular
signal‐regulated kinase 1 ( ERK 1) signalling pathway play pivotal roles in hepatic stellate cell ( …

Glycinamide ribonucleotide transformylase (GART) is a folate-dependent enzyme in the de
novo purine pathway that has been the target of antineoplastic intervention for almost 2 …

Early mitotic inhibitor-1 (Emi1) is a key cell-cycle regulator that promotes S-phase and M-phase
entry by inhibiting anaphase-promoting complex/cyclosome (APC/C) activity. …

PD-L1 and PD-L2 are important targets for immune checkpoint blockade, but how tumor
cells achieve their expression remains to be addressed. Here, we find that PD-L1 and PD-L2 …

Background and aim Nucleolar and spindle-associated protein 1 (NUSAP1) is an indispensable
mitotic regulator. Aberrant NUSAP1 expression is associated with perturbed mitosis and …

Hepatic stellate cell (HSC) activation is a key cellular event in the development of liver fibrosis.
Peroxisome proliferator-activated receptor-γ (PPARγ) has been shown to function as a …

Exosomes are discrete populations of small (40-200 nm in diameter) membranous vesicles
that are released into the extracellular space by most cell types, eventually accumulating in …