In the pursuit of clean pharmaceutical production, chemists in medicinal industry require
access to new sustainable methodologies to reduce and even eliminate pollution, which is …

The bovine represents an important agriculture species and dairy breeds have experienced
intense genetic selection over the last decades. The selection of breeders focused initially …

A rapid and efficient organocatalytic cascade sequence for the direct construction of
spirocyclopentane bioxindoles has been carried out by using a chiral squaramide catalyst in the …

Ein einfacher Weg zu Komplexität: Die Titelreaktion liefert Spirooxindole mit hoher
Enantioselektivität (siehe Schema). Entscheidend für die Reaktivität sind das nucleophile C4‐ und …

In mice and humans, sleep quantity is governed by genetic factors and exhibits age-dependent
variation 1 , 2 – 3 . However, the core molecular pathways and effector mechanisms that …

Aims: Many men endure immunosuppressive or anticancer treatments that contain
alkylating agents before the age of sexual maturity, especially the increasing number of …

A new chiral bis-phosphoric acid 3l bearing triple axial chirality was synthesized and
applied to effect a highly enantioselective 1,3-dipolar cycloaddition reaction between N,N′-…

Mechanochemically activated magnesium(0) metal as a highly active mediator driving direct
C-4–H alkylation of pyridines with alkyl halides has been developed. Excellent …

Spirocyclic oxindoles are the structural motifs frequently found in many natural products and
biologically active molecules.[1] Among them, spiropyrrolidine oxindoles are known for their …

A novel method to synthesize 4-alkylpyrimidines by the mechanochemical magnesium-mediated
Minisci reaction of pyrimidine derivatives and alkyl halides has been reported. The …