Human epidermal growth factor receptor 2 (HER2) status is one of the major tumor characteristics
in breast cancer to guide therapy. Anti-HER2 treatment has clear survival advantages …

Nanobodies (Nbs), the variable domains of camelid heavy chain-only antibodies, are a
promising class of therapeutics or in vivo imaging reagents entering the clinic. They possess …

Allergy prevalence has increased in industrialized countries. One contributing factor could be
pollution, which can cause nitration of allergens exogenously (in the air) or endogenously (…

Nitration of the major birch pollen allergen Bet v 1 alters the immune responses toward this
protein, but the underlying chemical mechanisms are not yet understood. Here we address …

A major impediment to successful use of therapeutic protein drugs is their ability to induce
anti-drug antibodies (ADA) that can alter treatment efficacy and safety in a significant number …

Background: The discovery of functional heavy chain-only antibodies devoid of light chains
in sera of camelids and sharks in the early nineties provided access to the generation of …

Many allergens share several biophysical characteristics, including the capability to undergo
oligomerization. The dimerization mechanism in Bet v 1 and its allergenic properties are so …

Nitration of tyrosine residues in the major birch pollen allergen Bet v 1 may alter the allergenic
potential of the protein. The kinetics and mechanism of the nitration reaction, however, …

Recombinant DNA technology has, in the last decades, contributed to a vast expansion of
the use of protein drugs as pharmaceutical agents. However, such biological drugs can lead …

WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT • Fabry disease is an X‐linked lysosomal
storage disorder related to α‐galactosidase A deficiency. • Two enzyme replacement …