Lifestyle factors are responsible for a considerable portion of cancer incidence worldwide,
but credible estimates from the World Health Organization and the International Agency for …

Cancer cells display a high rate of glycolysis in the presence of oxygen to promote proliferation.
Gluconeogenesis, the reverse pathway of glycolysis, can antagonize aerobic glycolysis …

While the epithelial-mesenchymal transition (EMT) plays a fundamental role during development,
its deregulation can adversely promote tumor metastasis. The phenotypic and cellular …

The epithelial-mesenchymal transition (EMT) enhances cancer invasiveness and confers
tumor cells with cancer stem cell (CSC)-like characteristics. We show that the Snail-G9a-Dnmt1 …

Breast cancers are highly heterogeneous but can be grouped into subtypes based on
several criteria, including level of expression of certain markers. Claudin-low breast cancer (CLBC…

Epithelial–mesenchymal transition (EMT) is a transdifferentiation programme. The mechanism
underlying the epigenetic regulation of EMT remains unclear. In this study, we identified …

Expression of E-cadherin, a hallmark of epithelial–mesenchymal transition (EMT), is often lost
due to promoter DNA methylation in basal-like breast cancer (BLBC), which contributes to …

Snail1, a key transcription factor of epithelial–mesenchymal transition (EMT), is subjected to
ubiquitination and degradation, but the mechanism by which Snail1 is stabilized in tumours …

Basal-like breast cancer (BLBC) is associated with high-grade, distant metastasis and poor
prognosis. Elucidating the determinants of aggressiveness in BLBC may facilitate the …

Since triple-negative breast cancer (TNBC) was first defined over a decade ago, increasing
studies have focused on its genetic and molecular characteristics. Patients diagnosed with …