Targeting cancer micrometastases with monoclonal antibodies: a binding-site barrier.

…, J Sato, S Kinuya, N Le, CH Paik… - Proceedings of the …, 1995 - National Acad Sciences
Monoclonal antibodies penetrate bulky tumors poorly after intravenous administration, in part
because of specific binding to the target antigen. Experiments presented here demonstrate …

Radioimmunotherapy of interleukin-2R alpha-expressing adult T-cell leukemia with Yttrium-90-labeled anti-Tac [see comments]

…, JD White, JA Carrasquillo, JC Reynolds, CH Paik… - 1995 - ashpublications.org
Adult T-cell leukemia (ATL) is a malignancy of mature lymphocytes caused by the retrovirus
human T-cell lymphotropic virus-I. It is an aggressive leukemia with a median survival time of …

Multimodal nanoprobes for radionuclide and five-color near-infrared optical lymphatic imaging

…, CAS Regino, IS Shin, BS Jang, N Le, CH Paik… - ACS …, 2007 - ACS Publications
Current contrast agents generally have one function and can only be imaged in monochrome;
therefore, the majority of imaging methods can only impart uniparametric information. A …

[PDF][PDF] Evaluation of the serum stability and in vivo biodistribution of CHX-DTPA and other ligands for yttrium labeling of monoclonal antibodies

…, OA Gansow, I Pastan, CH Paik… - Journal of nuclear …, 1994 - Soc Nuclear Med
Evaluation of the Serum Stability and In Vivo Biodistribution of CFIX-DTPA and Other
Ligands for Yttrium Labeling of Monoclonal Page 1 the evaluation of several alternative …

[HTML][HTML] Photoimmunotherapy: comparative effectiveness of two monoclonal antibodies targeting the epidermal growth factor receptor

…, H Hanaoka, T Harada, T Nakajima, I Kim, CH Paik… - Molecular …, 2014 - Elsevier
Photoimmunotherapy (PIT) is a new cancer treatment that combines the specificity of antibodies
for targeting tumors with the toxicity induced by photosensitizers after exposure to near …

[PDF][PDF] Growth performance and antibody response of broiler chicks fed yeast derived β-glucan and single-strain probiotics

BK An, BL Cho, SJ You, HD Paik, HI Chang… - … Australasian Journal of …, 2008 - animbiosci.org
A study was conducted to evaluate the effects of dietary yeast derived β-glucan and single-strain
probiotics on the growth performance and antibody response in broiler chicks. Six …

Evaluation of the in vivo biodistribution of indium-111 and yttrium-88 labeled dendrimer-1B4M-DTPA and its conjugation with anti-Tac monoclonal antibody

H Kobayashi, C Wu, MK Kim, CH Paik… - Bioconjugate …, 1999 - ACS Publications
We evaluated the in vivo biodistribution of indium- and yttrium-labeled second-generation
polyamidoamine dendrimer (PAMAM) conjugated with 2-(p-isothiocyanatobenzyl)-6-methyl-…

Pulsed high-intensity focused ultrasound enhances uptake of radiolabeled monoclonal antibody to human epidermoid tumor in nude mice

…, I Pastan, KCP Li, CH Paik - Journal of Nuclear …, 2008 - Soc Nuclear Med
The aim of this study was to determine if pulsed high-intensity focused ultrasound (HIFU)
exposures could enhance tumor uptake of 111 In-MX-B3, a murine IgG1κ monoclonal antibody …

The pharmacokinetic characteristics of glycolated humanized anti-Tac Fabs are determined by their isoelectric points

…, JE Pie, D Drumm, DS Paik, TA Waldmann, CH Paik… - Cancer research, 1999 - AACR
To evaluate a method for preventing the nephrotoxicity caused by the high renal accumulation
of radiolabeled or toxin-conjugated small immunoproteins used for cancer therapy, we …

Photoimmunotherapy targeting prostate-specific membrane antigen: are antibody fragments as effective as antibodies?

…, T Harada, M Mitsunaga, I Kim, CH Paik… - Journal of Nuclear …, 2015 - Soc Nuclear Med
Photoimmunotherapy is a highly cell-selective cancer therapy based on an armed antibody
conjugate with a phthalocyanine-based photosensitizer, IR700. Photoimmunotherapy …