Glioblastoma cell–derived lncRNA-containing exosomes induce microglia to produce complement C5, promoting chemotherapy resistance

Z Li, X Meng, P Wu, C Zha, B Han, L Li, N Sun… - Cancer Immunology …, 2021 - AACR
Caijun Zha; Caijun Zha … Ziwei Li, Xiangqi Meng, Pengfei Wu, Caijun Zha, Bo Han, Lulu Li,
Nan Sun, Tengfei Qi, Jie Qin, Yangong Zhang, Kaifu Tian, Shupeng Li, Changxiao Yang, Lejia …

[HTML][HTML] Neutrophil extracellular traps mediate the crosstalk between glioma progression and the tumor microenvironment via the HMGB1/RAGE/IL-8 axis

C Zha, X Meng, L Li, S Mi, D Qian, Z Li… - Cancer Biology & …, 2020 - ncbi.nlm.nih.gov
Objective: Neutrophil extracellular traps (NETs) produced by tumor-infiltrating neutrophils (TINs)
are associated with poor prognosis in patients with several types of cancer. However, …

[HTML][HTML] Dual functionalized brain-targeting nanoinhibitors restrain temozolomide-resistant glioma via attenuating EGFR and MET signaling pathways

X Meng, Y Zhao, B Han, C Zha, Y Zhang, Z Li… - Nature …, 2020 - nature.com
Activation of receptor tyrosine kinase (RTK) protein is frequently observed in malignant
progression of gliomas. In this study, the crosstalk activation of epidermal growth factor receptor (…

[HTML][HTML] ATRX/EZH2 complex epigenetically regulates FADD/PARP1 axis, contributing to TMZ resistance in glioma

B Han, X Meng, P Wu, Z Li, S Li, Y Zhang, C Zha… - Theranostics, 2020 - ncbi.nlm.nih.gov
Rationale: Glioma is the most common primary malignant brain tumor in adults. Chemoresistance
of temozolomide (TMZ), the first-line chemotherapeutic agent, is a major issue in the …

[HTML][HTML] DNA damage repair alterations modulate M2 polarization of microglia to remodel the tumor microenvironment via the p53-mediated MDK expression in …

X Meng, C Duan, H Pang, Q Chen, B Han, C Zha… - …, 2019 - thelancet.com
Background DNA damage repair (DDR) alterations are important events in cancer initiation,
progression, and therapeutic resistance. However, the involvement of DDR alterations in …

[HTML][HTML] NoncoRNA: a database of experimentally supported non-coding RNAs and drug targets in cancer

L Li, P Wu, Z Wang, X Meng, C Zha, Z Li, T Qi… - Journal of Hematology & …, 2020 - Springer
NoncoRNA ( http://www.ncdtcdb.cn:8080/NoncoRNA/ ) is a manually curated database of
experimentally supported non-coding RNAs (ncRNAs) and drug target associations that aim to …

Platelet-derived microparticles stimulated by anti-β2GPI/β2GPI complexes induce pyroptosis of endothelial cells in antiphospholipid syndrome

L Di, C Zha, Y Liu - Platelets, 2023 - Taylor & Francis
Platelet microparticles (PMPs) are vesicles that are released by platelets into the extracellular
space and play a role in antiphospholipid antibody syndromes. PMPs have recently been …

Tumor cell–derived TGFβ1 attenuates antitumor immune activity of T cells via regulation of PD-1 mRNA

…, B Geng, Q Chen, E Zhao, J Liu, C Sun, C Zha… - Cancer immunology …, 2020 - AACR
Dysfunction in T-cell antitumor activity contributes to the tumorigenesis, progression, and
poor outcome of clear cell renal cell carcinoma (ccRCC), with this dysfunction resulting from …

Anti-β2GPI/β2GPI induces neutrophil extracellular traps formation to promote thrombogenesis via the TLR4/MyD88/MAPKs axis activation

C Zha, W Zhang, F Gao, J Xu, R Jia, J Cai, Y Liu - Neuropharmacology, 2018 - Elsevier
Antiphospholipid antibodies (aPLs) are a large group of heterogeneous antibodies that bind
to anionic phospholipids alone or in combination with phospholipid binding proteins. …

[HTML][HTML] Platelets activated by the anti-β2GPI/β2GPI complex release microRNAs to inhibit migration and tube formation of human umbilical vein endothelial cells

Y Zhang, W Zhang, C Zha, Y Liu - Cellular & Molecular Biology Letters, 2018 - Springer
Background Patients with anti-β2GPI antibodies display significantly higher platelet
activation/aggregation and vascular endothelial cell damage. The mechanism underlying the …