Fusion genes are chromosomal aberrations that are found in many cancers and can be used
as prognostic markers and drug targets in clinical practice. Fusions can lead to production …

Studies over the past decades have uncovered fusion genes, a class of oncogenes that
provide immense diagnostic and therapeutic advantages because of their tumor-specific …

The emergence of fibroblast growth factor receptor (FGFR) family fusions across diverse
cancers has brought attention to FGFR‐derived cancer therapies. The discovery of the first …

Objective While abnormalities in myelin in tuberous sclerosis complex ( TSC ) have been
known for some time, recent imaging‐based data suggest myelin abnormalities may be …

A major rate-limiting step in developing more effective immunotherapies for GBM is our
inadequate understanding of the cellular complexity and the molecular heterogeneity of immune …

Myelin abnormalities are increasingly being recognized as an important component of a
number of neurologic developmental disorders. The integration of many signaling pathways …

Background MicroRNAs (miRs) are promising new therapeutics for glioblastoma. However,
which miRs are most effective against glioblastomas and how these miRs should be …

Ovarian carcinoma is the most lethal gynaecological malignancy. Better understanding of
the molecular pathogenesis of this disease and effective targeted therapies are needed to …

Epithelial-to-mesenchymal transition (EMT) and its reverse process, mesenchymal-to-epithelial
transition (MET), play important roles in embryogenesis, stem cell biology, and cancer …

Cancer genomics is a rapidly growing discipline in which the genetic molecular basis of
malignancy is studied at the scale of whole genomes. While the discipline has been successful …