Use of lung-specific exosomes for miRNA-126 delivery in non-small cell lung cancer

H Nie, X Xie, D Zhang, Y Zhou, B Li, F Li, F Li, Y Cheng… - Nanoscale, 2020 - pubs.rsc.org
Engineered exosomes have become popular drug delivery carriers for cancer treatment.
This is partially due to the interesting property, ie exosome organotropism, which plays an …

[HTML][HTML] Simultaneous blocking of CD47 and PD-L1 increases innate and adaptive cancer immune responses and cytokine release

S Lian, R Xie, Y Ye, X Xie, S Li, Y Lu, B Li, Y Cheng… - …, 2019 - thelancet.com
Background Treatment multiple tumors by immune therapy can be achieved by mobilizing
both innate and adaptive immunity. The programmed death ligand 1 (PD-L1; or CD274, B7-H1…

Fibronectin 1 promotes melanoma proliferation and metastasis by inhibiting apoptosis and regulating EMT

B Li, W Shen, H Peng, Y Li, F Chen, L Zheng… - OncoTargets and …, 2019 - Taylor & Francis
Background and aims The complex process of cancer metastasis remains the least understood.
Tumor cells alter their protein expression profile to survive from the tumor metastasis. …

[HTML][HTML] Eliminating blood oncogenic exosomes into the small intestine with aptamer-functionalized nanoparticles

…, S Lian, H Mei, Y Lu, H Dong, F Li, T Li, B Li… - Nature …, 2019 - nature.com
There are disease-causing biohazards in the blood that cannot be treated with modern
medicines. Here we show that an intelligently designed safe biomaterial can precisely identify, …

Near-infrared/pH dual-responsive nanocomplexes for targeted imaging and chemo/gene/photothermal tri-therapies of non-small cell lung cancer

Z Li, L Zhu, W Liu, Y Zheng, X Li, J Ye, B Li, H Chen… - Acta Biomaterialia, 2020 - Elsevier
Combination therapy offers promising opportunities for treating advanced non-small cell
lung cancer (NSCLC). Here, we established a chitosan-based nanocomplex CE7Q/CQ/S to …

[HTML][HTML] Identification of core genes and pathways in melanoma metastasis via bioinformatics analysis

R Xie, B Li, L Jia, Y Li - International Journal of Molecular Sciences, 2022 - mdpi.com
Metastasis is the leading cause of melanoma-related mortality. Current therapies are rarely
curative for metastatic melanoma, revealing the urgent need to identify more effective …

[HTML][HTML] Co-delivery of sorafenib and metapristone encapsulated by CXCR4-targeted PLGA-PEG nanoparticles overcomes hepatocellular carcinoma resistance to …

N Zheng, W Liu, B Li, H Nie, J Liu, Y Cheng… - Journal of Experimental …, 2019 - Springer
Background Sorafenib is approved as a standard therapy for advanced hepatocellular
carcinoma (HCC), but its clinical application is limited due to moderate therapeutic efficacy and …

Co-delivery of erlotinib and doxorubicin by MoS2 nanosheets for synergetic photothermal chemotherapy of cancer

J Liu, J Zheng, H Nie, H Chen, B Li, L Jia - Chemical Engineering Journal, 2020 - Elsevier
Time-staggered administration of erlotinib (Er) and doxorubicin (DOX) provides significantly
enhanced apoptosis of lung cancer cells, but this administration approach has not been …

Tumor-derived exosomes can specifically prevent cancer metastatic organotropism

X Xie, S Lian, Y Zhou, B Li, Y Lu, I Yeung… - Journal of Controlled …, 2021 - Elsevier
Each type of cancer has its own specific metastatic route developed by disseminating circulating
tumor cells (CTCs) and related extracellular vesicles to the target organ, ie, metastasis …

Molybdenum disulfide-based hyaluronic acid-guided multifunctional theranostic nanoplatform for magnetic resonance imaging and synergetic chemo-photothermal …

…, J Zheng, H Nie, D Zhang, D Cao, Z Xing, B Li… - Journal of colloid and …, 2019 - Elsevier
The construction of multifunctional theranostic nanoplatforms to integrate accurate imaging
and enhanced therapy to treat tumors is highly attractive but remains a challenge. Here, we …