uPAR-induced cell adhesion and migration: vitronectin provides the key
CD Madsen, GMS Ferraris, A Andolfo… - The Journal of cell …, 2007 - rupress.org
Expression of the membrane receptor uPAR induces profound changes in cell morphology
and migration, and its expression correlates with the malignant phenotype of cancers. To …
and migration, and its expression correlates with the malignant phenotype of cancers. To …
IL-1β+ macrophages fuel pathogenic inflammation in pancreatic cancer
…, A Citro, MSF Ng, M Schiavo Lena, D Drago, A Andolfo… - Nature, 2023 - nature.com
Pancreatic ductal adenocarcinoma (PDAC) is a lethal disease with high resistance to
therapies 1 . Inflammatory and immunomodulatory signals co-exist in the pancreatic tumour …
therapies 1 . Inflammatory and immunomodulatory signals co-exist in the pancreatic tumour …
[HTML][HTML] Butyrate, a postbiotic of intestinal bacteria, affects pancreatic cancer and gemcitabine response in in vitro and in vivo models
…, TP Latiano, A Potenza, A Andolfo… - Biomedicine & …, 2022 - Elsevier
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer. The characteristic
excessive stromatogenesis accompanying the growth of this tumor is believed to contribute to …
excessive stromatogenesis accompanying the growth of this tumor is believed to contribute to …
[HTML][HTML] Dimerization controls the lipid raft partitioning of uPAR/CD87 and regulates its biological functions
O Cunningham, A Andolfo, ML Santovito… - The EMBO …, 2003 - embopress.org
The urokinase-type plasminogen activator receptor (uPAR/CD87) is a
glycosylphosphatidylinositol-anchored membrane protein with multiple functions in extracellular …
glycosylphosphatidylinositol-anchored membrane protein with multiple functions in extracellular …
The serine protease hepsin mediates urinary secretion and polymerisation of Zona Pellucida domain protein uromodulin
…, S Perucca, L Han, A Cattaneo, F Consolato, A Andolfo… - Elife, 2015 - elifesciences.org
10.7554/eLife.08887.001 Uromodulin is the most abundant protein in the urine. It is exclusively
produced by renal epithelial cells and it plays key roles in kidney function and disease. …
produced by renal epithelial cells and it plays key roles in kidney function and disease. …
Tubulin acetyltransferase αTAT1 destabilizes microtubules independently of its acetylation activity
…, D Bilbao-Cortes, K Fiedorczuk, A Andolfo… - … and cellular biology, 2013 - Taylor & Francis
Acetylation of α-tubulin at lysine 40 (K40) is a well-conserved posttranslational modification
that marks long-lived microtubules but has poorly understood functional significance. …
that marks long-lived microtubules but has poorly understood functional significance. …
[PDF][PDF] Circulating IGF-I and IGFBP3 levels control human colonic stem cell function and are disrupted in diabetic enteropathy
The role of circulating factors in regulating colonic stem cells (CoSCs) and colonic epithelial
homeostasis is unclear. Individuals with long-standing type 1 diabetes (T1D) frequently …
homeostasis is unclear. Individuals with long-standing type 1 diabetes (T1D) frequently …
[HTML][HTML] Insight on colorectal carcinoma infiltration by studying perilesional extracellular matrix
M Nebuloni, L Albarello, A Andolfo, C Magagnotti… - Scientific reports, 2016 - nature.com
The extracellular matrix (ECM) from perilesional and colorectal carcinoma (CRC), but not
healthy colon, sustains proliferation and invasion of tumor cells. We investigated the …
healthy colon, sustains proliferation and invasion of tumor cells. We investigated the …
[HTML][HTML] HDAC3 is a molecular brake of the metabolic switch supporting white adipose tissue browning
…, G Cermenati, F Gilardi, B Desvergne, A Andolfo… - Nature …, 2017 - nature.com
White adipose tissue (WAT) can undergo a phenotypic switch, known as browning, in response
to environmental stimuli such as cold. Post-translational modifications of histones have …
to environmental stimuli such as cold. Post-translational modifications of histones have …
[HTML][HTML] Urokinase regulates vitronectin binding by controlling urokinase receptor oligomerization
N Sidenius, A Andolfo, R Fesce, F Blasi - Journal of Biological Chemistry, 2002 - ASBMB
Adhesion of monocytes to the extracellular matrix is mediated by a direct high affinity interaction
between cell-surface urokinase-type plasminogen activator (uPA) receptor (uPAR) and …
between cell-surface urokinase-type plasminogen activator (uPA) receptor (uPAR) and …