Tumor imaging using a picomolar affinity HER2 binding affibody molecule
A Orlova, M Magnusson, TLJ Eriksson, M Nilsson… - Cancer research, 2006 - AACR
The detection of cell-bound proteins that are produced due to aberrant gene expression in
malignant tumors can provide important diagnostic information influencing patient …
malignant tumors can provide important diagnostic information influencing patient …
Molecular imaging of HER2-expressing malignant tumors in breast cancer patients using synthetic 111In-or 68Ga-labeled affibody molecules
…, D Müller, C Schuchardt, A Orlova… - Journal of nuclear …, 2010 - Soc Nuclear Med
The clinical utility of a human epidermal growth factor receptor 2 (HER2)–targeting Affibody
molecule for detection and characterization of HER2-positive lesions was investigated in …
molecule for detection and characterization of HER2-positive lesions was investigated in …
Radionuclide Therapy of HER2-Positive Microxenografts Using a 177Lu-Labeled HER2-Specific Affibody Molecule
A radiolabeled anti-HER2 Affibody molecule (Z HER2:342 ) targets HER2-expressing xenografts
with high selectivity and gives good imaging contrast. However, the small size (∼7 kDa…
with high selectivity and gives good imaging contrast. However, the small size (∼7 kDa…
[HTML][HTML] Measuring HER2-receptor expression in metastatic breast cancer using [68Ga] ABY-025 Affibody PET/CT
…, A Wennborg, J Feldwisch, V Tolmachev, A Orlova… - Theranostics, 2016 - ncbi.nlm.nih.gov
Purpose: Positron Emission Tomography (PET) imaging of HER2 expression could potentially
be used to select patients for HER2-targed therapy, predict response based on uptake …
be used to select patients for HER2-targed therapy, predict response based on uptake …
Synthetic affibody molecules: a novel class of affinity ligands for molecular imaging of HER2-expressing malignant tumors
The Affibody molecule Z HER2:342-pep2 , site-specifically and homogeneously conjugated
with a 1,4,7,10-tetra-azacylododecane-N,N′,N″,N‴-tetraacetic acid (DOTA) chelator, was …
with a 1,4,7,10-tetra-azacylododecane-N,N′,N″,N‴-tetraacetic acid (DOTA) chelator, was …
Intrinsic chirality of CdSe/ZnS quantum dots and quantum rods
A new class of chiral nanoparticles is of great interest not only for nanotechnology, but also
for many other fields of scientific endeavor. Normally the chirality in semiconductor …
for many other fields of scientific endeavor. Normally the chirality in semiconductor …
Directed evolution to low nanomolar affinity of a tumor-targeting epidermal growth factor receptor-binding affibody molecule
M Friedman, A Orlova, E Johansson… - Journal of molecular …, 2008 - Elsevier
The epidermal growth factor receptor 1 (EGFR) is overexpressed in various malignancies
and is associated with a poor patient prognosis. A small, receptor-specific, high-affinity …
and is associated with a poor patient prognosis. A small, receptor-specific, high-affinity …
[HTML][HTML] Pharmacologic inhibition of STAT5 in acute myeloid leukemia
…, A Berger-Becvar, ED de Araujo, A Orlova… - Leukemia, 2018 - nature.com
The transcription factor STAT5 is an essential downstream mediator of many tyrosine kinases
(TKs), particularly in hematopoietic cancers. STAT5 is activated by FLT3-ITD, which is a …
(TKs), particularly in hematopoietic cancers. STAT5 is activated by FLT3-ITD, which is a …
On the selection of a tracer for PET imaging of HER2-expressing tumors: direct comparison of a 124I-labeled affibody molecule and trastuzumab in a murine xenograft …
A Orlova, H Wållberg, S Stone-Elander… - Journal of Nuclear …, 2009 - Soc Nuclear Med
Human epidermal growth factor receptor type 2 (HER2) is a tyrosine kinase, which is often
overexpressed in many carcinomas. Imaging HER2 expression in malignant tumors can …
overexpressed in many carcinomas. Imaging HER2 expression in malignant tumors can …
Imaging of EGFR expression in murine xenografts using site-specifically labelled anti-EGFR 111In-DOTA-ZEGFR:2377 Affibody molecule: aspect of the injected …
…, M Hansson, A Wennborg, A Orlova - European journal of …, 2010 - Springer
Introduction Overexpression of epidermal growth factor receptor (EGFR) is a prognostic and
predictive biomarker in a number of malignant tumours. Radionuclide molecular imaging of …
predictive biomarker in a number of malignant tumours. Radionuclide molecular imaging of …