Immunoconjugates—monoclonal antibodies (mAbs) coupled to highly toxic agents,
including radioisotopes and toxic drugs (ineffective when administered systemically alone)—are …

A novel engineered antibody fragment (V L -V H -C H 3, or “minibody”) with bivalent binding
to carcinoembryonic antigen (CEA) was produced by genetic fusion of a T84.66 (anti-CEA) …

This study evaluates the influence of particle size, PEGylation, and surface coating on the
quantitative biodistribution of near‐infrared‐emitting quantum dots (QDs) in mice. Polymer‐ or …

Luciferases, which have seen expansive employment as reporter genes in biological
research, could also be used in applications where the protein itself is conjugated to ligands to …

While chemotherapy delivery by nanocarriers has modestly improved the survival prospects
of pancreatic ductal adenocarcinoma (PDAC), additional engagement of the immune …

The use of R. reniformis luciferase (RLuc) as a reporter gene in small-animal imaging has
been hampered by its 481 nm peaked emission spectrum, as blue wavelengths are strongly …

Noninvasive molecular imaging approaches include nuclear, optical, magnetic resonance
imaging, computed tomography, ultrasound, and photoacoustic imaging, which require …

The rapidly advancing field of cancer immunotherapy is currently limited by the scarcity of
noninvasive and quantitative technologies capable of monitoring the presence and …

An improved approach composed of an oxidation reaction in acidic H 2 O 2 solution and a
sequential silanization reaction using neat silane reagents for surface modification of poly(…

Prolonged clearance kinetics have hampered the development of intact antibodies as
imaging agents, despite their ability to effectively deliver radionuclides to tumor targets in vivo. …