Antigen sensitivity of CD22-specific chimeric TCR is modulated by target epitope distance from the cell membrane
…, Y Lin, J Wang, BG Till, AA Raubitschek… - The Journal of …, 2008 - journals.aai.org
We have targeted CD22 as a novel tumor-associated Ag for recognition by human CTL
genetically modified to express chimeric TCR (cTCR) recognizing this surface molecule. CD22-…
genetically modified to express chimeric TCR (cTCR) recognizing this surface molecule. CD22-…
124I-labeled engineered anti-CEA minibodies and diabodies allow high-contrast, antigen-specific small-animal PET imaging of xenografts in athymic mice
…, RD Finn, SM Larson, AA Raubitschek… - Journal of Nuclear …, 2003 - Soc Nuclear Med
Prolonged clearance kinetics have hampered the development of intact antibodies as
imaging agents, despite their ability to effectively deliver radionuclides to tumor targets in vivo. …
imaging agents, despite their ability to effectively deliver radionuclides to tumor targets in vivo. …
Tailoring the pharmacokinetics and positron emission tomography imaging properties of anti–carcinoembryonic antigen single-chain Fv-Fc antibody fragments
…, LE Williams, JE Shively, D Colcher, AA Raubitschek… - Cancer research, 2005 - AACR
Antibody fragments are recognized as promising vehicles for delivery of imaging and therapeutic
agents to tumor sites in vivo. The serum persistence of IgG1 and fragments with intact …
agents to tumor sites in vivo. The serum persistence of IgG1 and fragments with intact …
High-resolution microPET imaging of carcinoembryonic antigen-positive xenografts by using a copper-64-labeled engineered antibody fragment
…, LE Williams, AA Raubitschek… - Proceedings of the …, 2000 - National Acad Sciences
Rapid imaging by antitumor antibodies has been limited by the prolonged targeting kinetics
and clearance of labeled whole antibodies. Genetically engineered fragments with rapid …
and clearance of labeled whole antibodies. Genetically engineered fragments with rapid …
Functional imaging of human epidermal growth factor receptor 2–positive metastatic breast cancer using 64Cu-DOTA-trastuzumab PET
…, JK Miles, JE Shively, AA Raubitschek - Journal of Nuclear …, 2014 - Soc Nuclear Med
Women with human epidermal growth factor receptor 2 (HER2)–positive breast cancer are
candidates for treatment with the anti-HER2 antibody trastuzumab. Assessment of HER2 …
candidates for treatment with the anti-HER2 antibody trastuzumab. Assessment of HER2 …
Covalent disulfide‐linked anti‐CEA diabody allows site‐specific conjugation and radiolabeling for tumor targeting applications
…, JE Shively, AA Raubitschek… - Protein Engineering …, 2004 - academic.oup.com
An engineered anti‐carcinoembryonic antigen (CEA) diabody (scFv dimer, 55 kDa) was
previously constructed from the murine anti‐CEA T84.66 antibody. Tumor targeting, imaging …
previously constructed from the murine anti‐CEA T84.66 antibody. Tumor targeting, imaging …
Multimerization of a chimeric anti-CD20 single-chain Fv-Fc fusion protein is mediated through variable domain exchange
…, T Olafsen, SJ Forman, AA Raubitschek - Protein …, 2001 - academic.oup.com
A series of single-chain anti-CD20 antibodies was produced by fusing single-chain Fv (scFv)
with human IgG1 hinge and Fc regions, designated scFv-Fc. The initial scFv-Fc construct …
with human IgG1 hinge and Fc regions, designated scFv-Fc. The initial scFv-Fc construct …
[PDF][PDF] Phase II trial of a transplantation regimen of yttrium-90 ibritumomab tiuxetan and high-dose chemotherapy in patients with non-Hodgkin's lymphoma
…, A Nademanee, HC Fung, AA Raubitschek… - Journal of clinical …, 2008 - academia.edu
Purpose This phase II trial evaluated the safety and efficacy of combining yttrium-90 (90Y)
ibritumomab tiuxetan with high-dose carmustine, cytarabine, etoposide, and melphalan (BEAM…
ibritumomab tiuxetan with high-dose carmustine, cytarabine, etoposide, and melphalan (BEAM…
Optimizing Radiolabeled Engineered Anti-p185HER2 Antibody Fragments for In vivo Imaging
…, SS Gambhir, LE Williams, JYC Wong, AA Raubitschek… - Cancer research, 2005 - AACR
We have recently described the in vivo properties of an iodinated anti-p185 HER2 engineered
antibody fragment [minibody (scFv-C H 3) 2 ; 80 kDa], made from the internalizing 10H8 …
antibody fragment [minibody (scFv-C H 3) 2 ; 80 kDa], made from the internalizing 10H8 …
Tumor targeting of radiometal labeled anti-CEA recombinant T84. 66 diabody and t84. 66 minibody: comparison to radioiodinated fragments
…, JYC Wong, JE Shively, AA Raubitschek - Bioconjugate …, 2001 - ACS Publications
Recombinant antibody fragments offer potential advantages over intact monoclonal antibodies
in the radioimmunoscintigraphy (RIS) of solid tumors. Due to their smaller molecular size, …
in the radioimmunoscintigraphy (RIS) of solid tumors. Due to their smaller molecular size, …