Hormone-stimulated lipolysis is a rapid way to mobilize fat from its storage depot for use in
peripheral tissues. By convention, activation of cytosolic lipases via the β-adrenergic receptor (…

Introduction Acquired resistance to osimertinib mediated by EGFR cis-C797S is now a
growing challenge. No effective treatment strategy is currently available to overcome cis-C797S–…

Background This study evaluated the efficacy and safety of anlotinib combined with programmed
cell death protein 1 (PD-1) blockade for the treatment of small-cell lung cancer (SCLC) …

Aims To characterise the mutational profiles of poorly differentiated thyroid carcinoma (PDTC)
and anaplastic thyroid carcinoma (ATC) and to identify markers with potential diagnostic, …

To understand the molecular mechanism of tumorigenesis of pulmonary lymphoepithelioma-like
carcinoma and explore potential therapeutic strategies, we investigated the genomic …

Currently, microsatellite instability (MSI) detection is limited to tissue samples with sufficient
tumor content. Detection of MSI from blood has been explored but confounded by low …

Introduction During nonreciprocal/reciprocal translocation process, 5′-anaplastic
lymphoma kinase (ALK) sometimes gets retained in the genome and is detectable by next-generation …

The data on the phenotypes associated with some rare germline mutations in Chinese breast
cancer patients are limited. The difference in somatic mutation profiles in breast cancer …

Background BRAF mutations occur in 2–4% non-small cell lung cancer (NSCLC) patients
and can be categorized into three functional classes based on signaling mechanism and …

Background The clinical utility of malignant pleural effusion (MPE) to detect mutation has
been well documented; however, routine practice of the use of MPE involves collection of the …