User profiles for Alan Wells
Alan WellsUniversity of Pittsburgh Verified email at upmc.edu Cited by 44015 |
EGF receptor
A Wells - The international journal of biochemistry & cell biology, 1999 - Elsevier
The receptor for the epidermal growth factor (EGF) and related ligands (EGFR), the prototypal
member of the superfamily of receptors with intrinsic tyrosine kinase activity, is widely …
member of the superfamily of receptors with intrinsic tyrosine kinase activity, is widely …
Migration of tumor cells in 3D matrices is governed by matrix stiffness along with cell-matrix adhesion and proteolysis
Cell migration on 2D surfaces is governed by a balance between counteracting tractile and
adhesion forces. Although biochemical factors such as adhesion receptor and ligand …
adhesion forces. Although biochemical factors such as adhesion receptor and ligand …
Cell adhesion and motility depend on nanoscale RGD clustering
…, G Brown, DA Lauffenburger, A Wells… - Journal of cell …, 2000 - journals.biologists.com
Integrin adhesion receptors play a crucial role in regulating interactions between cells and
extracellular matrix (ECM). Integrin activation initiates multiple intracellular signaling …
extracellular matrix (ECM). Integrin activation initiates multiple intracellular signaling …
Localized biphasic changes in phosphatidylinositol-4, 5-bisphosphate at sites of phagocytosis
Phagocytosis requires localized and transient remodeling of actin filaments. Phosphoinositide
signaling is believed to play an important role in cytoskeletal organization, but it is unclear …
signaling is believed to play an important role in cytoskeletal organization, but it is unclear …
Male attractiveness and differential testosterone investment in zebra finch eggs
Good-genes hypotheses of sexual selection predict that offspring fathered by preferred males
should have increased viability resulting from superior genetic quality. Several studies of …
should have increased viability resulting from superior genetic quality. Several studies of …
[HTML][HTML] Breast carcinoma cells re-express E-cadherin during mesenchymal to epithelial reverting transition
Background Epithelial to mesenchymal transition (EMT), implicated as a mechanism for tumor
dissemination, is marked by loss of E-cadherin, disruption of cell adhesion, and induction …
dissemination, is marked by loss of E-cadherin, disruption of cell adhesion, and induction …
Cutting to the chase: calpain proteases in cell motility
Calpains are a large family of intracellular proteases whose precise and limited cleavage of
specific proteins might be an integral regulatory aspect of signaling pathways. This intriguing …
specific proteins might be an integral regulatory aspect of signaling pathways. This intriguing …
E-cadherin as an indicator of mesenchymal to epithelial reverting transitions during the metastatic seeding of disseminated carcinomas
Cancer metastasis follows a sequential series of events, and many of the critical steps are
distinctly similar to EMT-like transformations that occur during normal embryonic development. …
distinctly similar to EMT-like transformations that occur during normal embryonic development. …
Mesenchymal–epithelial transition (MET) as a mechanism for metastatic colonisation in breast cancer
NPAD Gunasinghe, A Wells, EW Thompson… - Cancer and Metastasis …, 2012 - Springer
As yet, there is no cure for metastatic breast cancer. Historically, considerable research
effort has been concentrated on understanding the processes of metastasis, how a primary …
effort has been concentrated on understanding the processes of metastasis, how a primary …
Ligand-induced transformation by a noninternalizing epidermal growth factor receptor
Identification of a mutant epidermal growth factor (EGF) receptor that does not undergo
downregulation has provided a genetic probe to investigate the role of internalization in ligand-…
downregulation has provided a genetic probe to investigate the role of internalization in ligand-…