Abstract Changes in DNA methylation (DNAm) are linked to aging. Here, we profile highly
conserved CpGs in 339 predominantly female mice belonging to the BXD family for which …

Drug-metabolizing enzymes (DMEs) have shown increasing importance in anticancer
therapy. It is not only due to their effect on activation or deactivation of anticancer drugs, but …

Scope Tomato consumption is associated with many health benefits including lowered risk
for developing certain cancers. It is hypothesized that tomato phytochemicals are …

Objective Our study was to elucidate the role of RNA helicase DEAD‐Box Helicase 17
(DDX17) in NAFLD and to explore its underlying mechanisms. Methods We created …

Purpose The cancer-associated fibroblasts (CAFs) are one of the most abundant
components of the tumor microenvironment (TME). CAFs have been implicated in tumor …

The prevalence of nonalcoholic fatty liver disease (NAFLD) is growing worldwide in
association with Western-style diet and increasing obesity. Lingonberry (Vaccinium vitis …

The liver is critical for the digestive and immune systems. Although the physiology and
pathology of liver have been well studied and many scRNA‐seq data are generated, a …

Obesity and associated nonalcoholic steatohepatitis (NASH) are on the rise globally. NASH
became an important driver of hepatocellular carcinoma (HCC) in recent years. Activation of …

The liver's remarkable regenerative capacity is orchestrated by several growth factors and
cytokines. Fibroblast growth factor receptor 3 (Fgfr3) is frequently overexpressed in …

Hexafluoropropylene oxide dimer acid (GenX) is an alternative to perfluorooctanoic acid
(PFOA), whose environmental concentration is close to its maximum allowable value …