The coronavirus disease 2019 (COVID-19) outbreak, caused by SARS-CoV-2, has rapidly
expanded to a global pandemic. However, numbers of infected cases, deaths, and mortality …

To control and prevent the current COVID-19 pandemic, the development of novel vaccines
is an emergent issue. In addition, we need to develop tools that can measure/monitor T-cell …

Conquering immunosuppression in tumor microenvironments is crucial for effective cancer
immunotherapy. It is well known that interleukin ( IL )‐6, a pleiotropic cytokine, is produced in …

Overcoming the immunosuppressive state in tumor microenvironments is a critical issue for
improving the efficacy of cancer immunotherapy. Interleukin ( IL )‐6, a pleiotropic cytokine, is …

Neurokinin 2 receptor (NK2R), a G protein‐coupled receptor for neurokinin A (NKA), a
tachykinin family member, regulates various physiological functions including pain response, …

It is unknown as to how liver metastases are correlated with host immune status in colorectal
cancer. In this study, we found that IL6, a proinflammatory cytokine produced in tumor-…

With the significant advances in cancer genomics using next-generation sequencing
technologies, genomic and molecular profiling-based precision medicine is used as a part of …

Recent advances in next-generation sequencing technologies have led to significant
improvements in cancer genomic research and cancer treatment. Through the use of …

Background Arginase-1 (ARG1), a urea cycle-related enzyme, catalyzes the hydrolysis of
arginine to urea and ornithine, which regulates the proliferation, differentiation, and function of …

Proliferation and programmed cell death are important in the formation of morphologic
structures and functional activity during CNS development. We used immunohistochemical and …