User profiles for Yaoqin Gong
Yaoqin GongKey Laboratory of Experimental Teratology, Ministry of Education, Institute of Molecular … Verified email at sdu.edu.cn Cited by 10511 |
[HTML][HTML] LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development
Y Gong, RB Slee, N Fukai, G Rawadi… - Cell, 2001 - cell.com
In humans, low peak bone mass is a significant risk factor for osteoporosis. We report that
LRP5, encoding the low-density lipoprotein receptor-related protein 5, affects bone mass …
LRP5, encoding the low-density lipoprotein receptor-related protein 5, affects bone mass …
[HTML][HTML] The secreted glycoprotein lubricin protects cartilage surfaces and inhibits synovial cell overgrowth
…, J Marcelino, MA Baker, Y Gong… - The Journal of …, 2005 - Am Soc Clin Investig
The long-term integrity of an articulating joint is dependent upon the nourishment of its cartilage
component and the protection of the cartilage surface from friction-induced wear. Loss-of-…
component and the protection of the cartilage surface from friction-induced wear. Loss-of-…
[PDF][PDF] Six novel missense mutations in the LDL receptor-related protein 5 (LRP5) gene in different conditions with an increased bone density
…, D Scopelliti, L Key, T Renton, C Bartels, Y Gong… - The American Journal of …, 2003 - cell.com
Bone is a dynamic tissue that is subject to the balanced processes of bone formation and
bone resorption. Imbalance can give rise to skeletal pathologies with increased bone density. …
bone resorption. Imbalance can give rise to skeletal pathologies with increased bone density. …
Heterozygous mutations in the gene encoding noggin affect human joint morphogenesis
Y Gong, D Krakow, J Marcelino, D Wilkin, D Chitayat… - Nature …, 1999 - nature.com
The secreted polypeptide noggin (encoded by the Nog gene) binds and inactivates members
of the transforming growth factor β superfamily of signalling proteins (TGFβ-FMs), such as …
of the transforming growth factor β superfamily of signalling proteins (TGFβ-FMs), such as …
Osteoporosis-pseudoglioma syndrome, a disorder affecting skeletal strength and vision, is assigned to chromosome region 11q12-13.
Osteoporosis-pseudoglioma syndrome (OPS) is an autosomal recessive disorder characterized
by severe juvenile-onset osteoporosis and congenital or juvenile-onset blindness. The …
by severe juvenile-onset osteoporosis and congenital or juvenile-onset blindness. The …
MiR‐182 overexpression in tumourigenesis of high‐grade serous ovarian carcinoma
Molecular pathogenesis of high‐grade serous ovarian carcinoma (HG‐SOC) is poorly
understood. Recent recognition of HG‐SOC precursor lesions, defined as serous tubal …
understood. Recent recognition of HG‐SOC precursor lesions, defined as serous tubal …
[HTML][HTML] Isoliensinine induces apoptosis in triple-negative human breast cancer cells through ROS generation and p38 MAPK/JNK activation
Isoliensinine, liensinine and neferine are major bisbenzylisoquinoline alkaloids in the seed
embryo of lotus (Nelumbo nucifera) and exhibit potential anti-cancer activity. Here, we …
embryo of lotus (Nelumbo nucifera) and exhibit potential anti-cancer activity. Here, we …
[PDF][PDF] CRL4B catalyzes H2AK119 monoubiquitination and coordinates with PRC2 to promote tumorigenesis
We reported that Cullin4B-Ring E3 ligase complex (CRL4B) is physically associated with
Polycomb-repressive complex 2 (PRC2). We showed that CRL4B possesses an intrinsic …
Polycomb-repressive complex 2 (PRC2). We showed that CRL4B possesses an intrinsic …
HMGA2 Overexpression-Induced Ovarian Surface Epithelial Transformation Is Mediated Through Regulation of EMT Genes
The AT-hook transcription factor HMGA2 is an oncogene involved in the tumorigenesis of
many malignant neoplasms. HMGA2 overexpression is common in both early and late-stage …
many malignant neoplasms. HMGA2 overexpression is common in both early and late-stage …
[PDF][PDF] Mutation in CUL4B, which encodes a member of cullin-RING ubiquitin ligase complex, causes X-linked mental retardation
We reevaluated a previously reported family with an X-linked mental retardation syndrome
and attempted to identify the underlying genetic defect. Screening of candidate genes in a 10-…
and attempted to identify the underlying genetic defect. Screening of candidate genes in a 10-…