Multidrug resistance (MDR) is a major obstacle to successful cancer treatment and is crucial
to cancer metastasis and relapse. Combination therapy is an effective strategy for …

The effective treatment of malignant brain glioma is hindered by the poor transport across the
blood–brain barrier (BBB) and the low penetration across the blood-tumor barrier (BTB). In …

Chemotherapy is one of the most important strategies for glioma treatment. However, the “impermeability”
of the blood–brain barrier (BBB) impedes most chemotherapeutics from …

Hybrid mesoporous silica nanoparticles (MSNs), which were synthesized using the co-condensation
method and engineered with unique redox-responsive gatekeepers, were …

Malignant brain tumors are characterized by three major physiological processes: proliferation,
angiogenesis, and invasion. Traditional cytotoxic chemotherapies (eg Paclitaxel) control …

Exosome-based liquid biopsy holds great potential in monitoring tumor progression. Current
exosome detection biosensors rely on signal amplification strategies to improve sensitivity; …

In this paper, we prepared a dual functional system based on dextrin-coated silver nanoparticles
which were further attached with iron oxide nanoparticles and cell penetrating peptide (…

Despite broad application of nanotechnology in neuroscience, the nanoneurotoxicity of
magnetic nanoparticles in primary hippocampal neurons remains poorly characterized. In …

The management of infected wounds is still an intractable challenge in clinic. Development
of antibacterial wound dressing is of great practical significance for wound management. …

Myocardial infarction (MI) is a major cause of mortality worldwide. The major limitation of
regenerative therapy for MI is poor cardiac retention of therapeutics, which results from an …