Cyclic GMP-AMP (cGAMP) synthase (cGAS) senses misplaced genomic, mitochondrial, and
microbial double-stranded DNA (dsDNA) to synthesize 2′3′-cGAMP that mobilizes …

TGF-β family signaling through Smads is conceptually a simple and linear signaling pathway,
driven by sequential phosphorylation, with type II receptors activating type I receptors, …

Transforming growth factor β (TGF-β) family signaling dictates highly complex programs of
gene expression responses, which are extensively regulated at multiple levels and vary …

Inflammatory stimuli activate ectodomain shedding of TNF-α, L-selectin, and other
transmembrane proteins. We show that p38 MAP kinase, which is activated in response to …

Innate DNA sensing via the cyclic GMP-AMP synthase–stimulator of interferon genes (cGAS–STING)
mechanism surveys microbial invasion and cellular damage and thus participates …

Sensing cytosolic DNA through the cGAS–STING pathway constitutes a widespread innate
immune mechanism to monitor cellular damage and microbial invasion. Evading this …

Ectodomain shedding mediated by tumor necrosis factor–α (TNF-α)–converting enzyme [TACE;
also known as ADAM17 (a disintegrin and metalloproteinase 17)] provides an important …

The Hippo pathway senses cellular conditions and regulates YAP/TAZ to control cellular
and tissue homeostasis, while TBK1 is central for cytosolic nucleic acid sensing and antiviral …

Small cell lung cancer (SCLC) has a high degree of plasticity and is characterized by a
remarkable response to chemotherapy followed by the development of resistance. Here, we use …

Regulating TGF-β receptor presentation provides an avenue to alter a cell's responsiveness
to TGF-β. We report that activation of the Erk MAP kinase pathway decreases the TGF-β-…