LILRB4 signalling in leukaemia cells mediates T cell suppression and tumour infiltration
M Deng, X Gui, J Kim, L Xie, W Chen, Z Li, L He… - Nature, 2018 - nature.com
Immune checkpoint blockade therapy has been successful in treating some types of cancer
but has not shown clinical benefits for treating leukaemia 1 . This result suggests that …
but has not shown clinical benefits for treating leukaemia 1 . This result suggests that …
Liver tumour immune microenvironment subtypes and neutrophil heterogeneity
…, M Feng, F Wang, J Cheng, Z Li, Q Zhan, M Deng… - Nature, 2022 - nature.com
The heterogeneity of the tumour immune microenvironment (TIME), organized by various
immune and stromal cells, is a major contributing factor of tumour metastasis, relapse and drug …
immune and stromal cells, is a major contributing factor of tumour metastasis, relapse and drug …
Inhibitory leukocyte immunoglobulin-like receptors: Immune checkpoint proteins and tumor sustaining factors
Inhibitory leukocyte immunoglobulin-like receptors (LILRBs 1-5) transduce signals via
intracellular immunoreceptor tyrosine-based inhibitory motifs (ITIMs) that recruit protein tyrosine …
intracellular immunoreceptor tyrosine-based inhibitory motifs (ITIMs) that recruit protein tyrosine …
A motif in LILRB2 critical for Angptl2 binding and activation
A better understanding of the interaction between extrinsic factors and surface receptors on
stem cells will greatly benefit stem cell research and applications. Recently, we showed that …
stem cells will greatly benefit stem cell research and applications. Recently, we showed that …
Sumoylation activates the transcriptional activity of Pax-6, an important transcription factor for eye and brain development
Q Yan, L Gong, M Deng, L Zhang… - Proceedings of the …, 2010 - National Acad Sciences
Pax-6 is an evolutionarily conserved transcription factor regulating brain and eye development.
Four Pax-6 isoforms have been reported previously. Although the longer Pax-6 isoforms (…
Four Pax-6 isoforms have been reported previously. Although the longer Pax-6 isoforms (…
Surgery combined with intraoperative hyperthermic intraperitoneal chemotherapy (IHIC) for gastric cancer: a systematic review and meta-analysis of randomised …
DH Mi, Z Li, KH Yang, N Cao, A Lethaby… - International Journal …, 2013 - Taylor & Francis
Background: Adjuvant intraoperative hyperthermic intraperitoneal chemotherapy (IHIC) is a
therapy which combines thermotherapy and intraperitoneal chemotherapy. It is theoretically …
therapy which combines thermotherapy and intraperitoneal chemotherapy. It is theoretically …
[HTML][HTML] A novel anti-LILRB4 CAR-T cell for the treatment of monocytic AML
To effectively improve treatment for acute myeloid leukemia (AML), new molecular targets
and therapeutic approaches need to be identified. Chimeric antigen receptor (CAR)-modified …
and therapeutic approaches need to be identified. Chimeric antigen receptor (CAR)-modified …
The basic leucine zipper transcription factor NFIL3 directs the development of a common innate lymphoid cell precursor
10.7554/eLife.04406.001 Innate lymphoid cells (ILCs) are recently identified lymphocytes
that limit infection and promote tissue repair at mucosal surfaces. However, the pathways …
that limit infection and promote tissue repair at mucosal surfaces. However, the pathways …
Leukocyte immunoglobulin-like receptor subfamily B: therapeutic targets in cancer
Inhibitory leukocyte immunoglobulin-like receptors (LILRBs 1–5) transduce signals via
intracellular immunoreceptor tyrosine-based inhibitory motifs that recruit phosphatases to …
intracellular immunoreceptor tyrosine-based inhibitory motifs that recruit phosphatases to …
Silencing of LINE-1 retrotransposons is a selective dependency of myeloid leukemia
Transposable elements or transposons are major players in genetic variability and genome
evolution. Aberrant activation of long interspersed element-1 (LINE-1 or L1) …
evolution. Aberrant activation of long interspersed element-1 (LINE-1 or L1) …
