[HTML][HTML] Comprehensive characterization of CRC with germline mutations reveals a distinct somatic mutational landscape and elevated cancer risk in the Chinese …
J Yao, Y Zhen, J Fan, Y Gong, Y Ye, S Guo… - Cancer Biology & …, 2022 - ncbi.nlm.nih.gov
Objective: Hereditary colorectal cancer (CRC) accounts for approximately 5%–10% of all
CRC cases. The full profile of CRC-related germline mutations and the corresponding …
CRC cases. The full profile of CRC-related germline mutations and the corresponding …
[HTML][HTML] The largest Chinese cohort study indicates homologous recombination pathway gene mutations as another major genetic risk factor for colorectal cancer with …
Y Xu, K Liu, C Li, M Li, F Liu, X Zhou, M Sun… - Research, 2023 - spj.science.org
While genetic factors were associated with over 30% of colorectal cancer (CRC) patients,
mutations in CRC-susceptibility genes were identified in only 5% to 10% of these patients …
mutations in CRC-susceptibility genes were identified in only 5% to 10% of these patients …
Population-wide screening for germline variants of hereditary cancer genes in 12K unselected Japanese colorectal cancers and 27K controls
M Fujita, X Liu, Y Iwasaki, C Terao, S Takata, C Inai… - bioRxiv, 2020 - biorxiv.org
Abstract Background & Aims Colorectal cancer (CRC) is one of the most common cancers in
Western countries and Japan. Currently, a few% of CRCs can be attributed to recognizable …
Western countries and Japan. Currently, a few% of CRCs can be attributed to recognizable …
Mutation spectrum of germline cancer susceptibility genes among unselected Chinese colorectal cancer patients
R Gong, Y He, XY Liu, HY Wang, LY Sun… - Cancer management …, 2019 - Taylor & Francis
Background: Genetic factors play an important role in colorectal cancer (CRC) risk, yet the
prevalence and spectrum of germline cancer susceptibility gene mutations among …
prevalence and spectrum of germline cancer susceptibility gene mutations among …
Germline mutational profile of Chinese patients under 70 years old with colorectal cancer
TJ Jiang, F Wang, YN Wang, JJ Hu… - Cancer …, 2020 - Wiley Online Library
Background Inherited susceptibility accounts for nearly one‐third of colorectal cancer (CRC)
predispositions and has an 80%‐100% lifetime risk of this disease. However, there are few …
predispositions and has an 80%‐100% lifetime risk of this disease. However, there are few …
[HTML][HTML] Population-based screening for hereditary colorectal cancer variants in Japan
Background & Aims Colorectal cancer (CRC) is one of the most common cancers in the
world. A small proportion of CRCs can be attributed to recognizable hereditary germline …
world. A small proportion of CRCs can be attributed to recognizable hereditary germline …
A one‐stop approach to diagnosing hereditary colorectal cancer in the Chinese population
C Li, W Song, Y Xu, T Guo, X Zhou… - Journal of …, 2023 - Wiley Online Library
Abstract Background and Aim The current procedure for identifying hereditary colorectal
cancer (HCRC) is time consuming in clinical practice. This study aimed to develop a time …
cancer (HCRC) is time consuming in clinical practice. This study aimed to develop a time …
Familial colorectal cancer, beyond Lynch syndrome
EM Stoffel, F Kastrinos - Clinical gastroenterology and hepatology, 2014 - Elsevier
Although 30% of individuals diagnosed with colorectal cancer (CRC) report a family history
of the disease, only 5% to 6% carry germline mutations in genes associated with known …
of the disease, only 5% to 6% carry germline mutations in genes associated with known …
Genetic predisposition to colorectal cancer: Implications for treatment and prevention
EM Stoffel, MB Yurgelun - Seminars in oncology, 2016 - Elsevier
Colorectal cancer (CRC) is the third most common cancer diagnosed in men and women
and approximately 5% of cases are associated with identifiable germline mutations …
and approximately 5% of cases are associated with identifiable germline mutations …
A review of the genetic background and tumour profiling in familial colorectal cancer
T van Wezel, A Middeldorp, JT Wijnen… - Mutagenesis, 2012 - academic.oup.com
Inherited predisposition plays a role in 10–30% of colorectal cancer (CRC) cases. Of the
large families with a clearly positive family history of CRC,∼ 40% is not affected by known …
large families with a clearly positive family history of CRC,∼ 40% is not affected by known …
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