User profiles for Hongquan Zhang
Hongquan ZhangAssociate Professor, University of Alberta Verified email at ualberta.ca Cited by 6433 |
DNA-mediated homogeneous binding assays for nucleic acids and proteins
The detection of nucleic acids and proteins is fundamental for studying their functions and
for the development of molecular diagnostics. These molecules carry out most biological …
for the development of molecular diagnostics. These molecules carry out most biological …
Binding‐induced DNA nanomachines triggered by proteins and nucleic acids
We introduce the concept and operation of a binding‐induced DNA nanomachine that can
be activated by proteins and nucleic acids. This new type of nanomachine harnesses specific …
be activated by proteins and nucleic acids. This new type of nanomachine harnesses specific …
Androgen-repressed phenotype in human prostate cancer
…, BQ Chen, Y Wang, H Zhang… - Proceedings of the …, 1996 - National Acad Sciences
An androgen-repressed human prostate cancer cell line, ARCaP, was established and
characterized. This cell line was derived from the ascites fluid of a patient with advanced …
characterized. This cell line was derived from the ascites fluid of a patient with advanced …
Binding-induced fluorescence turn-on assay using aptamer-functionalized silver nanocluster DNA probes
We present here a binding-induced fluorescence turn-on assay for protein detection. Key
features of this assay include affinity binding-induced DNA hybridization and fluorescence …
features of this assay include affinity binding-induced DNA hybridization and fluorescence …
Dynamic DNA assemblies mediated by binding-induced DNA strand displacement
Dynamic DNA assemblies, including catalytic DNA circuits, DNA nanomachines, molecular
translators, and reconfigurable nanostructures, have shown promising potential to regulate …
translators, and reconfigurable nanostructures, have shown promising potential to regulate …
Molecular diagnosis of COVID-19: challenges and research needs
Molecular diagnosis of COVID-19 primarily relies on the detection of RNA of the SARS-CoV-2
virus, the causative infectious agent of the pandemic. Reverse transcription polymerase …
virus, the causative infectious agent of the pandemic. Reverse transcription polymerase …
[HTML][HTML] A microRNA-initiated DNAzyme motor operating in living cells
Synthetic DNA motors have great potential to mimic natural protein motors in cells but the
operation of synthetic DNA motors in living cells remains challenging and has not been …
operation of synthetic DNA motors in living cells remains challenging and has not been …
[HTML][HTML] Derivation of pluripotent stem cells with in vivo embryonic and extraembryonic potency
…, A He, Y Du, T Wang, C Zhao, H Li, X Chi, H Zhang… - Cell, 2017 - cell.com
Of all known cultured stem cell types, pluripotent stem cells (PSCs) sit atop the landscape of
developmental potency and are characterized by their ability to generate all cell types of an …
developmental potency and are characterized by their ability to generate all cell types of an …
Myosin-X provides a motor-based link between integrins and the cytoskeleton
H Zhang, JS Berg, Z Li, Y Wang, P Lång, AD Sousa… - Nature cell …, 2004 - nature.com
Unconventional myosins are actin-based motors with a growing number of attributed
functions 1 . Interestingly, it has been proposed that integrins are transported by unidentified …
functions 1 . Interestingly, it has been proposed that integrins are transported by unidentified …
[HTML][HTML] Aptamer binding assays for proteins: the thrombin example—a review
Experimentally selected single-stranded DNA and RNA aptamers are able to bind to specific
target molecules with high affinity and specificity. Many analytical methods make use of …
target molecules with high affinity and specificity. Many analytical methods make use of …