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Dicoumarol, an NQO1 inhibitor, blocks cccDNA transcription by promoting degradation of HBx.
Cheng ST, Hu JL, Ren JH, Yu HB, Zhong S, Wai Wong VK, Kwan Law BY, Chen WX, Xu HM, Zhang ZZ, Cai XF, Hu Y, Zhang WL, Long QX, Ren F, Zhou HZ, Huang AL, Chen J. Cheng ST, et al. Among authors: wai wong vk. J Hepatol. 2021 Mar;74(3):522-534. doi: 10.1016/j.jhep.2020.09.019. Epub 2020 Sep 25. J Hepatol. 2021. PMID: 32987030 Free article.
NAD(P)H: Quinone oxidoreductase 1 overexpression in hepatocellular carcinoma potentiates apoptosis evasion through regulating stabilization of X-linked inhibitor of apoptosis protein.
Li WY, Zhou HZ, Chen Y, Cai XF, Tang H, Ren JH, Wai Wong VK, Kwan Law BY, Chen Y, Cheng ST, Yu HB, Cai HY, Chen WX, Tang N, Zhang WL, Tao NN, Yang QX, Ren F, He L, Jiang H, Huang AL, Chen J. Li WY, et al. Among authors: wai wong vk. Cancer Lett. 2019 Jun 1;451:156-167. doi: 10.1016/j.canlet.2019.02.053. Epub 2019 Mar 10. Cancer Lett. 2019. PMID: 30867140
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