Abstract
A 41-year-old man with a huge pancreatic tumor (acinar cell carcinoma) was treated by intra-arterial infusion chemotherapy with 5-fluorouracil (5-FU), mitomycin C (MMC) and cisplatin (CDDP). The tumor was significantly reduced, and he underwent a pancreaticoduodenectomy with complete excision of the tumor. Unfortunately multiple metastatic liver tumors were noted 5 months after resection. These tumors could also be markedly reduced by intra-arterial chemotherapy and the survival period was prolonged to 18 months. He suddenly died of sepsis but not from the pancreatic carcinoma. This case shows that intra-arterial infusion chemotherapy with 5-FU, MMC and CDDP can be an effective regimen for the treatment of acinar cell carcinoma of the pancreas.
MeSH terms
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Adult
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Angiography
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Antibiotics, Antineoplastic / administration & dosage
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Antimetabolites, Antineoplastic
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Antineoplastic Combined Chemotherapy Protocols / administration & dosage*
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use
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Carcinoma, Acinar Cell / diagnosis
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Carcinoma, Acinar Cell / drug therapy*
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Carcinoma, Acinar Cell / surgery
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Cisplatin / administration & dosage
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Combined Modality Therapy
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Fatal Outcome
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Fluorouracil / administration & dosage
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Humans
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Injections, Intra-Arterial
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Male
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Mitomycins / administration & dosage
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Pancreatic Neoplasms / diagnosis
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Pancreatic Neoplasms / drug therapy*
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Pancreatic Neoplasms / surgery
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Pancreaticoduodenectomy
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Tomography, X-Ray Computed
Substances
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Antibiotics, Antineoplastic
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Antimetabolites, Antineoplastic
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Mitomycins
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Cisplatin
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Fluorouracil