Genotyping cell-free tumor DNA in the blood to detect residual disease and drug resistance

Genome Biol. 2014 Aug 30;15(8):449. doi: 10.1186/s13059-014-0449-4.

Abstract

DNA fragments released from cancer cells into the blood can be used to generate molecular profiles of tumors. Non-invasive 'liquid biopsies' can be used to monitor minimal residual disease and detect the emergence of drug resistance.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Cell-Free System
  • DNA, Neoplasm / analysis*
  • Drug Resistance, Neoplasm*
  • Genotype
  • Humans
  • Neoplasm, Residual / diagnosis*
  • Neoplasms / blood*
  • Neoplasms / genetics*
  • Neoplasms / pathology

Substances

  • DNA, Neoplasm