A new Lnc in metastasis: long noncoding RNA mediates the prometastatic functions of TGF-β

Cancer Cell. 2014 May 12;25(5):557-9. doi: 10.1016/j.ccr.2014.04.014.

Abstract

TGF-β signaling promotes metastasis by controlling the expression of downstream target genes. In this issue of Cancer Cell, Yuan and colleagues discover a novel TGF-β-induced lncRNA, lncRNA-ATB, which stimulates EMT through sequestering miR-200s and facilitates colonization by stabilizing IL-11 mRNA, thus promoting both early and late steps of cancer metastasis.

Publication types

  • Comment

MeSH terms

  • Animals
  • Carcinoma, Hepatocellular / genetics*
  • Carcinoma, Hepatocellular / pathology*
  • Humans
  • Liver Neoplasms / genetics*
  • Liver Neoplasms / pathology*
  • Male
  • RNA, Long Noncoding / genetics*
  • Transforming Growth Factor beta / metabolism*

Substances

  • RNA, Long Noncoding
  • Transforming Growth Factor beta