Abstract
Mouse models for cancer are revealing novel cancer-promoting roles for autophagy. Autophagy promotes tumor growth by suppressing the p53 response, maintaining mitochondrial function, sustaining metabolic homeostasis and survival in stress, and preventing diversion of tumor progression to benign oncocytomas.
Copyright © 2013 Elsevier Inc. All rights reserved.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
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Review
MeSH terms
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Animals
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Autophagy*
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Carcinogenesis*
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Humans
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Neoplasms / metabolism*
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Neoplasms / pathology
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Tumor Suppressor Protein p53 / metabolism
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ras Proteins / metabolism
Substances
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Tumor Suppressor Protein p53
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ras Proteins