Abstract
Many factors are considered to contribute to hepatitis B virus (HBV) associated hepatocellular carcinoma (HCC), including products of HBV, HBV integration and mutation, and host susceptibility. HBV X protein (HBx) can interfere with several signal pathways that associated with cell proliferation and apoptosis, and the impact of HBx C-terminal truncation in the development of HCC has been implicated. Recent studies by advanced sequencing technologies have revealed recurrent HBV DNA integration sites in hepatoma cells and susceptible genes/SNPs play an important role in the pathogenesis of liver cancer. Epigenetic changes, immune and inflammatory factors are also important contributing factors for liver cancer. This mini-review provides an overview on the recent development of HBV induced HCC.
Keywords:
Carcinogenesis; HBV; HBVx; HCC.
Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.
MeSH terms
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Animals
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Carcinoma, Hepatocellular / genetics
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Carcinoma, Hepatocellular / immunology
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Carcinoma, Hepatocellular / metabolism
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Carcinoma, Hepatocellular / virology*
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Cell Transformation, Viral*
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Disease Progression
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Gene Expression Regulation, Neoplastic
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Gene Expression Regulation, Viral
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Genotype
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Hepatitis B / complications*
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Hepatitis B / genetics
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Hepatitis B / immunology
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Hepatitis B / metabolism
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Hepatitis B virus / genetics
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Hepatitis B virus / immunology
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Hepatitis B virus / metabolism
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Hepatitis B virus / pathogenicity*
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Humans
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Inflammation Mediators / metabolism
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Liver Neoplasms / genetics
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Liver Neoplasms / immunology
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Liver Neoplasms / metabolism
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Liver Neoplasms / virology*
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Prognosis
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Risk Factors
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Signal Transduction
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Trans-Activators / genetics
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Trans-Activators / metabolism
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Viral Regulatory and Accessory Proteins
Substances
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Inflammation Mediators
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Trans-Activators
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Viral Regulatory and Accessory Proteins
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hepatitis B virus X protein