A Central role for mTOR in lipid homeostasis

Dudley W Lamming; David M Sabatini

doi:10.1016/j.cmet.2013.08.002

A Central role for mTOR in lipid homeostasis

Cell Metab. 2013 Oct 1;18(4):465-9. doi: 10.1016/j.cmet.2013.08.002. Epub 2013 Aug 22.

Authors

Dudley W Lamming¹, David M Sabatini

Affiliation

¹ Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA; Department of Biology, Massachusetts Institute of Technology (MIT), Cambridge, MA 02139, USA; Howard Hughes Medical Institute, MIT, Cambridge, MA 02139, USA; Broad Institute of Harvard and MIT, 7 Cambridge Center, Cambridge, MA 02142, USA; The David H. Koch Institute for Integrative Cancer Research at MIT, Cambridge, MA 02139, USA.

Abstract

The mechanistic target of rapamycin (mTOR) signaling pathway regulates many fundamental metabolic and physiological processes, including lipid metabolism. We explore recent findings on the role of mTOR in lipid homeostasis, with an emphasis on recent findings from in vivo models regarding the role of mTORC2 in lipolysis, lipogenesis, and adipogenesis.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

MeSH terms

Adipogenesis
Adipose Tissue / metabolism
Humans
Lipid Metabolism / physiology*
Lipogenesis
Lipolysis
Liver / metabolism
Signal Transduction
TOR Serine-Threonine Kinases / metabolism*

Substances

MTOR protein, human
TOR Serine-Threonine Kinases

Abstract

Publication types

MeSH terms

Substances

Grants and funding