Down-regulation of GnT-V inhibits nasopharyngeal carcinoma cell CNE-2 malignancy in vitro and in vivo

Ting Wei; Yahui Li; Enqing Zhuo; Weiliang Zhu; Hui Meng; Jian Zhang

doi:10.1016/j.canlet.2011.05.029

Down-regulation of GnT-V inhibits nasopharyngeal carcinoma cell CNE-2 malignancy in vitro and in vivo

Cancer Lett. 2011 Oct 28;309(2):151-61. doi: 10.1016/j.canlet.2011.05.029. Epub 2011 Jun 14.

Authors

Ting Wei¹, Yahui Li, Enqing Zhuo, Weiliang Zhu, Hui Meng, Jian Zhang

Affiliation

¹ Department of Oncology, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China.

PMID: 21676538
DOI: 10.1016/j.canlet.2011.05.029

Abstract

To investigate the role of N-acetylglucosaminyltransferases V (GnT-V) in the development of human nasopharyngeal carcinoma (NPC) both in vitro and in vivo, the GnT-V stably suppressed cell line CNE-2 GnT-V/2224 was constructed from CNE-2. The studies indicated that down-regulation of GnT-V inhibited the proliferation, migration and invasion abilities of the NPC cell line CNE-2. The radio sensitivity of CNE-2 was enhanced after down-regulation of GnT-V, which may be associated with the decreased expression of bcl-2.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Apoptosis
Carcinoma
Cell Adhesion / genetics
Cell Cycle
Cell Line, Tumor
Cell Proliferation
Down-Regulation
Gene Expression Regulation, Neoplastic
Humans
Mice
Mice, Nude
N-Acetylglucosaminyltransferases / genetics*
N-Acetylglucosaminyltransferases / metabolism*
Nasopharyngeal Carcinoma
Nasopharyngeal Neoplasms / genetics*
Nasopharyngeal Neoplasms / metabolism
Nasopharyngeal Neoplasms / pathology*
Neoplasm Invasiveness
Radiation Tolerance

Substances

N-Acetylglucosaminyltransferases
alpha-1,6-mannosylglycoprotein beta 1,6-N-acetylglucosaminyltransferase