Abstract
Interleukin-33 (IL-33) is a member of the IL-1 cytokine family, which includes IL-1 and IL-18. IL-33 is considered to be crucial for induction of Th2-type cytokine-associated immune responses such as host defense against nematodes and allergic diseases by inducing production of such Th2-type cytokines as IL-5 and IL-13 by Th2 cells, mast cells, basophils and eosinophils. In addition, IL-33 is involved in the induction of non-Th2-type acute and chronic inflammation as a proinflammatory cytokine, similar to IL-1 and IL-18. In this review, we summarize and discuss the current knowledge regarding the roles of IL-33 and IL-33 receptors in host defense and disease development.
MeSH terms
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Animals
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Autoimmune Diseases / genetics
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Autoimmune Diseases / immunology*
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Host-Pathogen Interactions
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Humans
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Hypersensitivity / genetics
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Hypersensitivity / immunology*
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Immunity
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Infections / genetics
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Infections / immunology*
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Inflammation
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Interleukin-1 Receptor-Like 1 Protein
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Interleukin-33
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Interleukins / immunology*
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Mice
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Polymorphism, Genetic
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Receptors, Cell Surface / immunology
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Receptors, Interleukin / immunology
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Th2 Cells / immunology*
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Toll-Like Receptors / immunology
Substances
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IL1RL1 protein, human
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IL33 protein, human
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Il1rl1 protein, mouse
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Interleukin-1 Receptor-Like 1 Protein
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Interleukin-33
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Interleukins
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Receptors, Cell Surface
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Receptors, Interleukin
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Toll-Like Receptors