Abstract
A recent report in Science from the Varmus laboratory (Podsypanina et al., 2008) puts an interesting twist on the origins of metastatic cells, suggesting that metastases can arise in ways that are very different from those widely believed.
MeSH terms
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Animals
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Cell Proliferation
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Cell Survival
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Cell Transformation, Neoplastic / metabolism
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Cell Transformation, Neoplastic / pathology
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Epithelial Cells / metabolism
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Epithelial Cells / pathology*
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Female
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Gene Expression Regulation, Neoplastic
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Lung Neoplasms / genetics
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Lung Neoplasms / metabolism
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Lung Neoplasms / secondary*
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Mammary Glands, Animal / metabolism
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Mammary Glands, Animal / pathology*
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Mammary Neoplasms, Experimental / genetics
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Mammary Neoplasms, Experimental / metabolism
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Mammary Neoplasms, Experimental / pathology*
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Mice
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Neoplasm Metastasis
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Neoplasm Seeding
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Neoplastic Cells, Circulating / metabolism
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Neoplastic Cells, Circulating / pathology*
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Proto-Oncogene Proteins c-myc / genetics
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Proto-Oncogene Proteins c-myc / metabolism*
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Proto-Oncogene Proteins p21(ras) / genetics
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Proto-Oncogene Proteins p21(ras) / metabolism*
Substances
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Proto-Oncogene Proteins c-myc
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Proto-Oncogene Proteins p21(ras)