Abstract
Metastasis is the major cause of mortality and morbidity for patients with cancer. The high-mobility group protein 1(Y) [HMG-1(Y)] has a role in the transcription of many genes involved at different steps in the metastatic cascade and has been linked with cancer in human and animal models. This may represent a potential therapeutic target for patients. The following review summarizes and critically appraises the evidence for the role of HMG-1(Y) in metastasis.
(c) 2004 Wiley-Liss, Inc.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Breast Neoplasms / chemistry
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Breast Neoplasms / pathology
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Cell Communication
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Cell Cycle
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Cell Line, Tumor
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Colorectal Neoplasms / chemistry
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Colorectal Neoplasms / pathology
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Female
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Genes, Tumor Suppressor
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HMGA1a Protein / biosynthesis
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HMGA1a Protein / genetics
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HMGA1a Protein / physiology*
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Humans
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Lymphoma / chemistry
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Lymphoma / pathology
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Male
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Neoplasm Metastasis / genetics*
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Neoplasm Metastasis / pathology*
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Neoplasms / chemistry*
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Neoplasms / genetics
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Neoplasms / pathology*
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Neuroblastoma / chemistry
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Neuroblastoma / pathology
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Oncogenes*
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Pancreatic Neoplasms / chemistry
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Pancreatic Neoplasms / pathology
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Prostatic Neoplasms / chemistry
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Prostatic Neoplasms / pathology
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RNA, Messenger / analysis
Substances
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RNA, Messenger
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HMGA1a Protein