High-mobility group protein 1(Y): metastasis-associated or metastasis-inducing?

J Surg Oncol. 2004 Nov 1;88(2):86-99. doi: 10.1002/jso.20136.

Abstract

Metastasis is the major cause of mortality and morbidity for patients with cancer. The high-mobility group protein 1(Y) [HMG-1(Y)] has a role in the transcription of many genes involved at different steps in the metastatic cascade and has been linked with cancer in human and animal models. This may represent a potential therapeutic target for patients. The following review summarizes and critically appraises the evidence for the role of HMG-1(Y) in metastasis.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Breast Neoplasms / chemistry
  • Breast Neoplasms / pathology
  • Cell Communication
  • Cell Cycle
  • Cell Line, Tumor
  • Colorectal Neoplasms / chemistry
  • Colorectal Neoplasms / pathology
  • Female
  • Genes, Tumor Suppressor
  • HMGA1a Protein / biosynthesis
  • HMGA1a Protein / genetics
  • HMGA1a Protein / physiology*
  • Humans
  • Lymphoma / chemistry
  • Lymphoma / pathology
  • Male
  • Neoplasm Metastasis / genetics*
  • Neoplasm Metastasis / pathology*
  • Neoplasms / chemistry*
  • Neoplasms / genetics
  • Neoplasms / pathology*
  • Neuroblastoma / chemistry
  • Neuroblastoma / pathology
  • Oncogenes*
  • Pancreatic Neoplasms / chemistry
  • Pancreatic Neoplasms / pathology
  • Prostatic Neoplasms / chemistry
  • Prostatic Neoplasms / pathology
  • RNA, Messenger / analysis

Substances

  • RNA, Messenger
  • HMGA1a Protein