The heparin binding 25 kDa fragment of thrombospondin-1 promotes angiogenesis and modulates gelatinase and TIMP-2 production in endothelial cells

FASEB J. 2000 Sep;14(12):1674-6. doi: 10.1096/fj.99-0931fje.
No abstract available

MeSH terms

  • Animals
  • Endothelium, Vascular / enzymology*
  • Endothelium, Vascular / metabolism
  • Endothelium, Vascular / physiology
  • Fibroblast Growth Factor 2 / antagonists & inhibitors
  • Gelatinases / metabolism*
  • Heparin / metabolism
  • Matrix Metalloproteinase 2 / metabolism
  • Molecular Weight
  • Neovascularization, Physiologic / physiology*
  • Peptide Fragments / physiology
  • Rabbits
  • Thrombospondin 1 / physiology*
  • Tissue Inhibitor of Metalloproteinase-2 / biosynthesis*
  • Tissue Inhibitor of Metalloproteinase-2 / metabolism

Substances

  • Peptide Fragments
  • Thrombospondin 1
  • Fibroblast Growth Factor 2
  • Tissue Inhibitor of Metalloproteinase-2
  • Heparin
  • Gelatinases
  • Matrix Metalloproteinase 2