Abstract
S-100 proteins (S100) are characterized by calcium-binding ability with two structural EF hands. Several S100 are expressed in cardiomyocytes and thought to play a crucial role in calcium signaling. To examine whether the expression of S100 is a response to detectable myocardial damage or regeneration, we investigated, immunohistochemically, the expression of S100A4 and S100A11 in the isoproterenol (ISP)-treated rat heart. Definite expression of S100A4 and S100A11 was demonstrated in normal cardiomyocytes, and their staining patterns were enhanced in the ISP-treated rat heart, suggesting the possible involvement of S1-A4 and S100A11 in ISP-induced myocardial damage.
MeSH terms
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Amino Acid Sequence
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Animals
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COS Cells
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Cardiomegaly / chemically induced
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Cardiomegaly / metabolism*
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Cardiomegaly / pathology
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Cloning, Molecular
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DNA, Complementary / chemistry
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DNA, Complementary / genetics
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Heart Ventricles / chemistry
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Heart Ventricles / drug effects
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Heart Ventricles / pathology
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Humans
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Immune Sera / immunology
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Immunohistochemistry
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Isoproterenol / adverse effects*
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Male
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Molecular Sequence Data
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Myocardium / chemistry
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Myocardium / pathology
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Rats
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Rats, Wistar
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S100 Calcium-Binding Protein A4
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S100 Proteins / analysis*
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S100 Proteins / genetics
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S100 Proteins / immunology
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Sequence Alignment
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Sequence Analysis, DNA
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Sequence Homology, Amino Acid
Substances
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DNA, Complementary
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Immune Sera
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S100 Calcium-Binding Protein A4
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S100 Proteins
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S100a4 protein, rat
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S100A4 protein, human
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S100A11 protein, human
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Isoproterenol