Abstract
A 52-year-old Japanese woman presented with a mass in the left breast. A tumor 2.9 cm in diameter was found in the D area on ultrasonography. An ipsilateral swollen axillary lymph node was detected. Invasion of the tumor to the pectoralis major muscle was seen. Based on a diagnosis of malignant lymphoma by fine needle aspiration cytology, radical mastectomy with ipsilateral axillary lymph node dissection was performed. Malignant diffuse large B-cell type lymphoma was diagnosed histologically according to the World Health Organization classification, and the clinical stage was IIE by the Ann Arbor staging system. Four courses of adjuvant chemotherapy with cyclophosphamide, doxorubicin, vincristine and prednisone (CHOP) were subsequently performed. The patient is free of recurrence 7 years after surgery. Up to 2002, 380 cases of primary breast non-Hodgkin’s lymphoma had been documented in the Japanese literature. When the tumor size was bigger than 4.5 cm, the outcome was poor. Regarding treatment methods, we showed that only enucleation of the tumor is necessary and axillary dissection is not necessary. In our case, we thought that the prognosis was good despite the large tumor and axillary lymph node metastasis, and that we could omit axillary dissection.
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Abbreviations
- WHO:
-
World health organization
- CHOP:
-
Cyclophosphamide,doxorubicin, vincristine and prednisone
- NHL:
-
Non-Hodgkin’slymphoma
- US:
-
Ultrasonography
- MRI:
-
Magnetic resonance imaging
- FNA:
-
Fine needle aspiration
References
Wiseman C, Liao KT: Primary lymphoma of the breast.Cancer 29:1705–1712, 1972.
Mambo NC, Burke JS, Butler JJ: Primary malignant lymphoma of the breast.Cancer 39:2033–2040, 1977.
Terasawa T: Primary non-epithelial malignant tumor of the breast.Jpn Cancer Therapy 18:1226–1233, 1983 (in Japanese).
Talvalker GV: Primary lymphosarcoma of the breast. A report of ten cases.Indian J Cancer 10:322–329, 1973.
Osada K, Okajima K, Ryo T, Kanemoto H, Miyoshi K, Taguchi T, Yamamoto R: Primary Malignant Lymphoma of The Breast -Review of Japanese literature and report of our three cases-.Oosaka Itaisi 50:69–75, 1991 (in Japanese with English abstract).
Wakabayashi H, Maeba T, Maeta H, Tanaka S: A Case of Primary Malignant Lymphoma of the Bilateral Breast. -A study of surgical treatment based on the clinicopathological evaluation of its local involvement and the postoperative recurrence site-.Jpn J Breast Cancer 9:675–680, 1994 (in Japanese with English abstract).
DeCosse JJ, Berg JW, Fracchia AA, Farrow JH: Primary Lymphosarcoma of the Breast.Cancer 15:1264–1268, 1961.
Brustein S, Kimmel M, Lieberman PH, Filippa DA, Rosen PP: Malignant Lymphoma of the Breast. A Study of 53 Patients.Ann Surg 205:144–150, 1987.
Yoshida Y: Reticulum cell sarcoma of the breast.Cancer 26:94–99, 1970.
Haagensen CD: Disease of the breast, 2nd ed, WB Sunders Co, Philadelphia, pp315–321, 1971.
Tanaka R, Iihara M, Wada Y, Kanbe M, Okamoto T, Ito Y, Nishikawa T, Izuo M, Obara T: Two Patients with Long Survival after Breast Conserving Surgery and Radiation for Primary Malignant Lymphoma of the Breast.Jpn J Cancer Clin 46:97–102, 2000 (in Japanese with English abstract).
Miller TP, Steve Dahlberg, Robert Cassady J, Adelstein DJ, Spier CM, Grogan TM, Leblanc M, Carlin S, Chase E, Fisher RI: Chemotherapy alone compared with Chemotherapy plus Radiotherapy for Localized Intermediate- And High-Grade Non-Hodgkin’s Lymphoma.N Engl J Med 339:21–26, 1998.
Smith M, Brunstein S, Straus DJ: Localized non-Hodgkin’s lymphoma of the breast.Cancer 59:351–354, 1987.
The International Non-Hodgkin’s Lymphoma Prognostic Factors Project: A predictive model for aggressive non-Hodgkin’s lymphoma.N Engl J Med 329:987–994, 1993.
Harris NL, Jaffe ES, Diebold J, Flandrin G, Muller-Hermelink HK, Vardiman J, Lister TA, Bloomfield CD: World health organization classification of neoplastic diseases of the hematopoietic and lymphoid tissues: report of the clinical advisory committee meeting-airlie house, Virginia, November 1997.Mod Pathol 13:193–207, 2000.
Freeman C, Berg JW, Cutler SJ: Occurrence and Prognosis of Extranodal Lymphomas.Cancer 29:252–260, 1972.
Horiguchi Y, Nakajima J, Matuno H: A Case Report of Malignant Tumor Originating from Bilateral Juvenile Breast.Nihon Geka Gatukai 50:386, 1950 (in Japanese).
Tanaka M, Nakamura H, Ooi H: Image Diagnosis of Malignant Lymphoma of the Breast.Rinshyou Houshyasen 30:117–119, 1985 (in Japanese with English abstract).
Hasegawa S, Kosaka A, Mori I: A case of primary malignant lymphoma of the breast.Nihon Rinshyou Geka 56:519–523, 1995 (in Japanese with English abstract).
Mori K, Inoue Y, Nishi T, Fukuuchi A, Ibukuro K, Tsukiyama T: Primary Malignant Lymphoma of the Breast: Mammographic and Ultrasonographic Findings.Breast Cancer 5:93–97, 1998.
Nagasawa S, Endo T, Aoyama H, Ichihara S: MR Imaging of the Primary Breast Lymphoma: A Case Report.Breast Cancer 3:209–213, 1996.
Tokui K, Sato M, Inoue H, Bando Y, Go S, Kimura S: A case of primary malignant lymphoma of the breast.Ehime Igaku 8:259–263, 1988 (in Japanese with English abstract).
Sogabe T, Kato Y, Chung YS, Kim K, Nishimura M, Maekawa H, Ogawa Y, Sowa M, Mitsuhashi T: Primary Malignant Lymphoma of the Breast-A case report & review of the literatures.Jpn J Cancer Clin 39:1583–1587, 1993 (in Japanese with English abstract).
Hinoshita E, Tashiro H, Takahashi I, Onohara T, Nishizaki T, Matsusaka T, Wakasugi K, Ishikawa T, Kume K, Yamamoto I, Hirota Y: Primary Non-Hodgkin’s Lymphoma of the Breast: A Report of Two Cases.Breast Cancer 5:309–312, 1998.
El-Ghazawy IM, Singletary SE: Surgical Management of Primary Lymphoma of the Breast.Ann Surg 214:724–726, 1991.
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Uesato, M., Miyazawa, Y., Gunji, Y. et al. Primary non-hodgkin’s lymphoma of the breast: Report of a case with special reference to 380 cases in the Japanese literature. Breast Cancer 12, 154–158 (2005). https://doi.org/10.2325/jbcs.12.154
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DOI: https://doi.org/10.2325/jbcs.12.154