Elsevier

Pancreatology

Volume 10, Issue 5, December 2010, Pages 553-564
Pancreatology

Biophotonics and Biotechnology in Pancreatic Cancer: Cyclic RGD-Peptide-Conjugated Type II Quantum Dots for in vivo Imaging

https://doi.org/10.1159/000283577Get rights and content

Abstract

This work introduces a novel, facile and straightforward approach to produce cyclic-RGD-peptide-conjugated type II CdTe/CdS quantum dot (QD) formulation for pancreatic tumor targeting and imaging in live animals. The ultra-small QDs were prepared by a hot colloidal synthesis method. Phospholipid micelles were then used to encapsulate the QDs, allowing them to be stably dispersed in biological fluids and able to conjugate with cyclic-RGD peptides. The QD complex had shown low cytotoxicity on Panc-1 human pancreatic cancer cell lines. In addition, the tissue sections and biodistribution of QD complexes were imaged and analyzed in mice bearing pancreatic tumor xenografts, confirming specific tumor targeting. These studies support further evaluation of type II QDs as potential probes for early pancreatic cancer assessment and detection.

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    Ken-Tye Yong School of Electrical and Electronic Engineering Nanyang Technological University Singapore 639798 (Singapore) Tel. +65 6790 5444, Fax +65 6793 3318

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