Abstract
The inability to repair DNA damage properly in mammals leads to various disorders and enhanced rates of tumour development. Organisms respond to chromosomal insults by activating a complex damage response pathway. This pathway regulates known responses such as cell-cycle arrest and apoptosis (programmed cell death), and has recently been shown to control additional processes including direct activation of DNA repair networks.
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Acknowledgements
We thank A. Carr, D. Cortez, M. Mattern, M. Huang, L. Zou, M. Tetzlaff and T. Weinert for comments on the manuscript.
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Zhou, BB., Elledge, S. The DNA damage response: putting checkpoints in perspective. Nature 408, 433–439 (2000). https://doi.org/10.1038/35044005
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DOI: https://doi.org/10.1038/35044005
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