Resistance of pancreatic cancer cells to oncolytic vesicular stomatitis virus: Role of type I interferon signaling
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Highlights
► We examined cellular responses of human pancreatic adenocarcinomas (PDA) to VSV. ► 11 PDA cell lines were examined for expression of type I IFN associated genes. ► All PDA cell lines, resistant and permissive, were able to sense VSV infection. ► Only resistant PDA cell lines displayed constitutive expression of MxA and OAS. ► Inhibition of JAK/STAT signaling both down regulated MxA and OAS and helped VSV.
Keywords
Vesicular stomatitis virus
Oncolytic virus
Virotherapy
Cancer
Interferon
Type I interferon
Anticancer therapy
Resistant cells
MxA
OAS
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These authors contributed equally to this work.
Copyright © 2012 Elsevier Inc. All rights reserved.