Elsevier

Journal of Hepatology

Volume 57, Issue 2, August 2012, Pages 430-441
Journal of Hepatology

Review
STAT proteins – Key regulators of anti-viral responses, inflammation, and tumorigenesis in the liver

https://doi.org/10.1016/j.jhep.2012.01.029Get rights and content
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open access

Summary

Since its discovery in the early 1990s, the Janus kinase (JAK)-signal transducer and activator of transcription (STAT) signaling pathway has been found to play key roles in regulating many key cellular processes such as survival, proliferation, and differentiation. There are seven known mammalian STAT family members: STAT1, 2, 3, 4, 5a, 5b, and 6. In the liver, activation of these STAT proteins is critical for anti-viral defense against hepatitis viral infection and for controlling injury, repair, inflammation, and tumorigenesis. The identification of functions for these STAT proteins has increased our understanding of liver disease pathophysiology and treatments, while also suggesting new therapeutic modalities for managing liver disease.

Abbreviations

CCl4
carbon tetrachloride
Con A
concanavalin A
HCC
hepatocellular carcinoma
HCV
hepatitis C virus
IL
interleukin
JAK
Janus kinase
NK
natural killer
SNP
single nucleotide polymorphism
SOCS
suppressor of cytokine signaling
STAT
signal transducer and activator of transcription

Keywords

HCV
Interferon
Liver injury
Liver regeneration
Liver tumor

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