Elsevier

Journal of Biotechnology

Volume 202, 20 May 2015, Pages 40-49
Journal of Biotechnology

Discovery and development of Seliciclib. How systems biology approaches can lead to better drug performance

https://doi.org/10.1016/j.jbiotec.2015.02.032Get rights and content
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Abstract

Seliciclib (R-Roscovitine) was identified as an inhibitor of CDKs and has undergone drug development and clinical testing as an anticancer agent. In this review, the authors describe the discovery of Seliciclib and give a brief summary of the biology of the CDKs Seliciclib inhibits. An overview of the published in vitro and in vivo work supporting the development as an anti-cancer agent, from in vitro experiments to animal model studies ending with a summary of the clinical trial results and trials underway is presented. In addition some potential non-oncology applications are explored and the potential mode of action of Seliciclib in these areas is described. Finally the authors argue that optimisation of the therapeutic effects of kinase inhibitors such as Seliciclib could be enhanced using a systems biology approach involving mathematical modelling of the molecular pathways regulating cell growth and division.

Keywords

Seliciclib
Systems biology
CDK

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