Cell
Volume 136, Issue 2, 23 January 2009, Pages 215-233
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Review
MicroRNAs: Target Recognition and Regulatory Functions

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MicroRNAs (miRNAs) are endogenous ∼23 nt RNAs that play important gene-regulatory roles in animals and plants by pairing to the mRNAs of protein-coding genes to direct their posttranscriptional repression. This review outlines the current understanding of miRNA target recognition in animals and discusses the widespread impact of miRNAs on both the expression and evolution of protein-coding genes.

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